Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018

Räisänen, Kati; Koivula, Irma; Ilmavirta, Heikki; Puranen, Santeri; Kallonen, Teemu; Lyytikäinen, Outi; Jalava, Jari

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Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018

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Title:	Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018
Author(s):	Räisänen, Kati ; Koivula, Irma ; Ilmavirta, Heikki ; Puranen, Santeri ; Kallonen, Teemu ; Lyytikäinen, Outi ; Jalava, Jari
Date:	2019-05-01
Language:	en
Pages:	1-3
Department:	National Institute for Health and Welfare University of Eastern Finland Helsinki Institute for Information Technology (HIIT) Department of Computer Science
Series:	EUROSURVEILLANCE, Volume 24, issue 19
ISSN:	1025-496X
DOI-number:	10.2807/1560-7917.ES.2019.24.19.1900256
Keywords:	carbapenem, ceftazidime-avibactam, Klebsiella pneumoniae, resistance, whole-genome sequencing, KPC-2
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Citation: Räisänen , K , Koivula , I , Ilmavirta , H , Puranen , S , Kallonen , T , Lyytikäinen , O & Jalava , J 2019 , ' Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018 ' , EUROSURVEILLANCE , vol. 24 , no. 19 , pp. 1-3 . https://doi.org/10.2807/1560-7917.ES.2019.24.19.1900256
Abstract: In December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing Klebsiella pneumoniae strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with blaKPC-2-producing K. pneumoniae ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site.

Permanent link to this item: http://urn.fi/URN:NBN:fi:aalto-201907304452 Email this Export to RefWorks QR Code Print BibTex Tweet