Biomimetic Photocurable Three-Dimensional Printed Nerve Guidance Channels with Aligned Cryomatrix Lumen for Peripheral Nerve Regeneration

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Singh, Anamika
dc.contributor.author Asikainen, Sanja
dc.contributor.author Teotia, Arun K.
dc.contributor.author Shiekh, Parvaiz A.
dc.contributor.author Huotilainen, Eero
dc.contributor.author Qayoom, Irfan
dc.contributor.author Partanen, Jouni
dc.contributor.author Seppälä, Jukka
dc.contributor.author Kumar, Ashok
dc.date.accessioned 2019-06-03T14:13:20Z
dc.date.available 2019-06-03T14:13:20Z
dc.date.issued 2018-12-19
dc.identifier.citation Singh , A , Asikainen , S , Teotia , A K , Shiekh , P A , Huotilainen , E , Qayoom , I , Partanen , J , Seppälä , J & Kumar , A 2018 , ' Biomimetic Photocurable Three-Dimensional Printed Nerve Guidance Channels with Aligned Cryomatrix Lumen for Peripheral Nerve Regeneration ' , ACS Applied Materials and Interfaces , vol. 10 , no. 50 , pp. 43327-43342 . https://doi.org/10.1021/acsami.8b11677 en
dc.identifier.issn 1944-8244
dc.identifier.issn 1944-8252
dc.identifier.other PURE UUID: 66aef69a-7de9-4c74-b3f7-ddc586b7f851
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/biomimetic-photocurable-threedimensional-printed-nerve-guidance-channels-with-aligned-cryomatrix-lumen-for-peripheral-nerve-regeneration(66aef69a-7de9-4c74-b3f7-ddc586b7f851).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85058666518&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/33920340/CHEM_Singh_Asikainen_et_al_Biomimetic_Photocurable_2018_ACS_App_Mater_Interf.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/38273
dc.description.abstract Repair and regeneration of critically injured peripheral nerves is one of the most challenging reconstructive surgeries. Currently available and FDA approved nerve guidance channels (NGCs) are suitable for small gap injuries, and their biological performance is inferior to that of autografts. Development of biomimetic NGCs with clinically relevant geometrical and biological characteristics such as topographical, biochemical, and haptotactic cues could offer better regeneration of the long-gap complex nerve injuries. Here, in this study, we present the development and preclinical analysis of three-dimensional (3D) printed aligned cryomatrix-filled NGCs along with nerve growth factor (NGF) (aCG + NGF) for peripheral nerve regeneration. We demonstrated the application of these aCG + NGF NGCs in the enhanced and successful regeneration of a critically injured rat sciatic nerve in comparison to random cryogel-filled NGCs, multichannel and clinically preferred hollow conduits, and the gold standard autografts. Our results indicated similar effect of the aCG + NGF NGCs viz-a-viz that of the autografts, and they not only enhanced the overall regenerated nerve physiology but could also mimic the cellular aspects of regeneration. This study emphasizes the paradigm that these biomimetic 3D printed NGCs will lead to a better functional regenerative outcome under clinical settings. en
dc.format.extent 16
dc.format.extent 43327-43342
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher AMER CHEMICAL SOC
dc.relation.ispartofseries ACS Applied Materials and Interfaces en
dc.relation.ispartofseries Volume 10, issue 50 en
dc.rights openAccess en
dc.subject.other Materials Science(all) en
dc.subject.other 215 Chemical engineering en
dc.subject.other 216 Materials engineering en
dc.title Biomimetic Photocurable Three-Dimensional Printed Nerve Guidance Channels with Aligned Cryomatrix Lumen for Peripheral Nerve Regeneration en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Indian Institute of Technology, Kanpur
dc.contributor.department Polymer technology
dc.contributor.department Department of Mechanical Engineering
dc.contributor.department Department of Chemical and Metallurgical Engineering
dc.subject.keyword 3D printing
dc.subject.keyword aligned cryogel
dc.subject.keyword guidance channel
dc.subject.keyword nerve regeneration
dc.subject.keyword stereolithography
dc.subject.keyword Materials Science(all)
dc.subject.keyword 215 Chemical engineering
dc.subject.keyword 216 Materials engineering
dc.identifier.urn URN:NBN:fi:aalto-201906033358
dc.identifier.doi 10.1021/acsami.8b11677
dc.date.embargo info:eu-repo/date/embargoEnd/2019-12-20


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