Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

 |  Login

Show simple item record

dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Markl, Daniel
dc.contributor.author Wang, Parry
dc.contributor.author Ridgway, Cathy
dc.contributor.author Karttunen, Anssi Pekka
dc.contributor.author Chakraborty, Mousumi
dc.contributor.author Bawuah, Prince
dc.contributor.author Pääkkönen, Pertti
dc.contributor.author Gane, Patrick
dc.contributor.author Ketolainen, Jarkko
dc.contributor.author Peiponen, Kai-Erik
dc.contributor.author Zeitler, J. Axel
dc.date.accessioned 2019-05-06T09:05:33Z
dc.date.available 2019-05-06T09:05:33Z
dc.date.issued 2017-05
dc.identifier.citation Markl , D , Wang , P , Ridgway , C , Karttunen , A P , Chakraborty , M , Bawuah , P , Pääkkönen , P , Gane , P , Ketolainen , J , Peiponen , K-E & Zeitler , J A 2017 , ' Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography ' Journal of Pharmaceutical Sciences , vol. 106 , no. 6 , pp. 1586–1595 . https://doi.org/10.1016/j.xphs.2017.02.028 en
dc.identifier.issn 0022-3549
dc.identifier.issn 1520-6017
dc.identifier.other PURE UUID: 0bdb0ac4-1a30-434e-97e6-6e3987f40150
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/characterization-of-the-pore-structure-of-functionalized-calcium-carbonate-tablets-by-terahertz-timedomain-spectroscopy-and-xray-computed-microtomography(0bdb0ac4-1a30-434e-97e6-6e3987f40150).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85017391273&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/32889923/1_s2.0_S0022354917301430_main.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/37598
dc.description.abstract Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45%-65% were prepared in 5% steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R 2 = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance. en
dc.format.extent 1586–1595
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher John Wiley and Sons Inc.
dc.relation.ispartofseries Journal of Pharmaceutical Sciences en
dc.relation.ispartofseries Volume 106, issue 6 en
dc.rights openAccess en
dc.subject.other Medicine(all) en
dc.subject.other Pharmaceutical Science en
dc.subject.other 1182 Biochemistry, cell and molecular biology en
dc.title Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department University of Cambridge
dc.contributor.department Omya International AG
dc.contributor.department University of Eastern Finland
dc.contributor.department Department of Bioproducts and Biosystems
dc.contributor.department Department of Bioproducts and Biosystems en
dc.subject.keyword Imaging methods
dc.subject.keyword Mathematical models
dc.subject.keyword Mechanical properties
dc.subject.keyword Physical characterization
dc.subject.keyword Refractive index
dc.subject.keyword Solid dosage form
dc.subject.keyword Spectroscopy
dc.subject.keyword Medicine(all)
dc.subject.keyword Pharmaceutical Science
dc.subject.keyword 1182 Biochemistry, cell and molecular biology
dc.identifier.urn URN:NBN:fi:aalto-201905062718
dc.identifier.doi 10.1016/j.xphs.2017.02.028
dc.type.version publishedVersion


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search archive


Advanced Search

article-iconSubmit a publication

Browse

My Account