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Waveforms of molecular oscillations reveal circadian timekeeping mechanisms

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Jo, Hang-Hyun
dc.contributor.author Kim, Yeon Jeong
dc.contributor.author Kim, Jae Kyoung
dc.contributor.author Foo, Mathias
dc.contributor.author Somers, David E.
dc.contributor.author Kim, Pan-Jun
dc.date.accessioned 2019-05-06T09:04:09Z
dc.date.available 2019-05-06T09:04:09Z
dc.date.issued 2018
dc.identifier.citation Jo , H-H , Kim , Y J , Kim , J K , Foo , M , Somers , D E & Kim , P-J 2018 , ' Waveforms of molecular oscillations reveal circadian timekeeping mechanisms ' , Communications Biology , vol. 1 , 207 , pp. 1-11 . https://doi.org/10.1038/s42003-018-0217-1 en
dc.identifier.issn 2399-3642
dc.identifier.other PURE UUID: 06a04e64-2ff9-4aff-97fc-f9cb2e09fde0
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/waveforms-of-molecular-oscillations-reveal-circadian-timekeeping-mechanisms(06a04e64-2ff9-4aff-97fc-f9cb2e09fde0).html
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/32925311/s42003_018_0217_1_1.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/37587
dc.description.abstract Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian timekeeping. We find that the cost of synthesizing proteins with particular waveforms can be substantially reduced by rhythmic protein half-lives over time, as supported by previous plant and mammalian data, as well as our own seedling experiment. We also find that previously enigmatic, cyclic expression of positive arm components within the mammalian and insect clocks allows both a broad range of peak time differences between protein waveforms and the symmetries of the waveforms about the peak times. Such various peak-time differences may facilitate tissue-specific or developmental stage-specific multicellular processes. Our waveform-guided approach can be extended to various biological oscillators, including cell-cycle and synthetic genetic oscillators. en
dc.format.extent 11
dc.format.extent 1-11
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher NATURE PUBLISHING GROUP
dc.relation.ispartofseries Communications Biology en
dc.relation.ispartofseries Volume 1 en
dc.rights openAccess en
dc.subject.other 113 Computer and information sciences en
dc.title Waveforms of molecular oscillations reveal circadian timekeeping mechanisms en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Computer Science
dc.contributor.department Ohio State University
dc.contributor.department Korea Advanced Institute of Science and Technology
dc.contributor.department Coventry University
dc.contributor.department Abdus Salam International Centre for Theoretical Physics
dc.subject.keyword GENE-EXPRESSION
dc.subject.keyword TARGETED DEGRADATION
dc.subject.keyword CLOCK
dc.subject.keyword RHYTHMS
dc.subject.keyword PHOSPHORYLATION
dc.subject.keyword QUANTIFICATION
dc.subject.keyword TRANSCRIPTION
dc.subject.keyword NEUROSPORA
dc.subject.keyword LESSONS
dc.subject.keyword MODELS
dc.subject.keyword 113 Computer and information sciences
dc.identifier.urn URN:NBN:fi:aalto-201905062707
dc.identifier.doi 10.1038/s42003-018-0217-1
dc.type.version publishedVersion


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