Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Asikainen, Sanja
dc.contributor.author Paakinaho, Kaarlo
dc.contributor.author Kyhkynen, Anna Kaisa
dc.contributor.author Hannula, Markus
dc.contributor.author Malin, Minna
dc.contributor.author Ahola, Niina
dc.contributor.author Kellomäki, Minna
dc.contributor.author Seppälä, Jukka
dc.date.accessioned 2019-03-05T10:14:01Z
dc.date.available 2019-03-05T10:14:01Z
dc.date.issued 2019-04-01
dc.identifier.citation Asikainen , S , Paakinaho , K , Kyhkynen , A K , Hannula , M , Malin , M , Ahola , N , Kellomäki , M & Seppälä , J 2019 , ' Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity ' , European Polymer Journal , vol. 113 , pp. 165-175 . https://doi.org/10.1016/j.eurpolymj.2019.01.056 en
dc.identifier.issn 0014-3057
dc.identifier.issn 1873-1945
dc.identifier.other PURE UUID: 0b11476e-456f-4c8b-937c-9b95b587eba2
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/hydrolysis-and-drug-release-from-polyethylene-glycolmodified-lactone-polymers-with-open-porosity(0b11476e-456f-4c8b-937c-9b95b587eba2).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85060767586&partnerID=8YFLogxK
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/36997
dc.description.abstract The ability to release active agents from a porous scaffold structure in situ enables the simultaneous structural support for the cells proliferating and differentiating towards tissue as well as the stimulation of tissue regeneration. Due to the great potentiality of such approach, drug-releasing scaffolds were fabricated from hydrolytically degradable polymers. Three copolymers of poly(ethylene glycol), ɛ-caprolactone, L- and D,L-lactide were synthesized and blended with bone-growth inducing active agents, dexamethasone (DM) and 2-phospho-L-ascorbic acid trisodium salt (AS). Porous scaffolds were prepared by means of super-critical carbon dioxide foaming. In the final scaffold structures, the particle size, location and the water solubility of the drug affected the release kinetics. As the large and water soluble AS particles were more exposed to the buffer solution compared to small DM particles, the AS release was burst-like whereas DM showed a long-term release. The material structure had a significant effect on the release kinetics as the porous scaffolds released active agents faster compared to the solid cylinders. Furthermore, this study showed the strong effect of polymer degradation and wettability on the release, which were more determinative than the pore architecture. en
dc.format.extent 11
dc.format.extent 165-175
dc.language.iso en en
dc.publisher Elsevier Limited
dc.relation.ispartofseries European Polymer Journal en
dc.relation.ispartofseries Volume 113 en
dc.rights embargoedAccess en
dc.subject.other Physics and Astronomy(all) en
dc.subject.other Organic Chemistry en
dc.subject.other Polymers and Plastics en
dc.subject.other Materials Chemistry en
dc.subject.other 215 Chemical engineering en
dc.title Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Chemical and Metallurgical Engineering
dc.contributor.department Tampere University
dc.contributor.department Polymer technology
dc.subject.keyword 2-Phospho-L-ascorbic acid trisodium salt
dc.subject.keyword Bulk degradation
dc.subject.keyword Dexamethasone
dc.subject.keyword Drug release
dc.subject.keyword Hydrolytic degradation
dc.subject.keyword Supercritical carbon dioxide foaming
dc.subject.keyword Physics and Astronomy(all)
dc.subject.keyword Organic Chemistry
dc.subject.keyword Polymers and Plastics
dc.subject.keyword Materials Chemistry
dc.subject.keyword 215 Chemical engineering
dc.identifier.urn URN:NBN:fi:aalto-201903052143
dc.identifier.doi 10.1016/j.eurpolymj.2019.01.056
dc.date.embargo info:eu-repo/date/embargoEnd/2021-02-01

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