Activation of the motivation-related ventral striatum during delusional experience

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Raij, Tuukka T. Riekki, Tapani J.J. Rikandi, Eva Mäntylä, Teemu Kieseppä, Tuula Suvisaari, Jaana 2019-01-14T09:24:31Z 2019-01-14T09:24:31Z 2018-12-01
dc.identifier.citation Raij , T T , Riekki , T J J , Rikandi , E , Mäntylä , T , Kieseppä , T & Suvisaari , J 2018 , ' Activation of the motivation-related ventral striatum during delusional experience ' TRANSLATIONAL PSYCHIATRY , vol. 8 , no. 1 , 283 , pp. 1-8 . DOI: 10.1038/s41398-018-0347-8 en
dc.identifier.issn 2158-3188
dc.identifier.other PURE UUID: d3b1be02-5fa1-477d-93b0-e2f7344ef49a
dc.identifier.other PURE ITEMURL:
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dc.description.abstract Delusion is the most characteristic symptom of psychosis, occurring in almost all first-episode psychosis patients. The motivational salience hypothesis suggests delusion to originate from the experience of abnormal motivational salience. Whether the motivation-related brain circuitries are activated during the actual delusional experience remains, however, unknown. We used a forced-choice answering tree at random intervals during functional magnetic resonance imaging to capture delusional and non-delusional spontaneous experiences in patients with first-episode psychosis (n = 31) or clinical high-risk state (n = 7). The motivation-related brain regions were identified by an automated meta-analysis of 149 studies. Thirteen first-episode patients reported both delusional and non-delusional spontaneous experiences. In these patients, delusional experiences were related to stronger activation of the ventral striatum in both hemispheres. This activation overlapped with the most strongly motivation-related brain regions. These findings provide an empirical link between the actual delusional experience and the motivational salience hypothesis. Further use and development of the present methods in localizing the neurobiological basis of the most characteristic symptoms may be useful in the search for etiopathogenic pathways that result in psychotic disorders. en
dc.format.extent 1-8
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries TRANSLATIONAL PSYCHIATRY en
dc.relation.ispartofseries Volume 8, issue 1 en
dc.rights openAccess en
dc.subject.other Psychiatry and Mental health en
dc.subject.other Cellular and Molecular Neuroscience en
dc.subject.other Biological Psychiatry en
dc.subject.other 3112 Neurosciences en
dc.title Activation of the motivation-related ventral striatum during delusional experience en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Neuroscience and Biomedical Engineering
dc.contributor.department University of Helsinki
dc.contributor.department National Institute for Health and Welfare
dc.subject.keyword Psychiatry and Mental health
dc.subject.keyword Cellular and Molecular Neuroscience
dc.subject.keyword Biological Psychiatry
dc.subject.keyword 3112 Neurosciences
dc.identifier.urn URN:NBN:fi:aalto-201901141207
dc.identifier.doi 10.1038/s41398-018-0347-8
dc.type.version publishedVersion

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