Controlled communication between physically separated bacterial populations in a microfluidic device

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Osmekhina, Ekaterina
dc.contributor.author Jonkergouw, Christopher
dc.contributor.author Schmidt, Georg
dc.contributor.author Jahangiri, Farzin
dc.contributor.author Jokinen, Ville
dc.contributor.author Franssila, Sami
dc.contributor.author Linder, Markus
dc.date.accessioned 2018-12-21T10:31:16Z
dc.date.available 2018-12-21T10:31:16Z
dc.date.issued 2018
dc.identifier.citation Osmekhina , E , Jonkergouw , C , Schmidt , G , Jahangiri , F , Jokinen , V , Franssila , S & Linder , M 2018 , ' Controlled communication between physically separated bacterial populations in a microfluidic device ' Communications Biology , vol. 1 , 97 . en
dc.identifier.issn 2399-3642
dc.identifier.other PURE UUID: 736d7c61-b2ea-44a9-9acc-da327014f932
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/controlled-communication-between-physically-separated-bacterial-populations-in-a-microfluidic-device(736d7c61-b2ea-44a9-9acc-da327014f932).html
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/30429617/CHEM_Osmekhina_et_al_Controlled_communication_between_Communications_Biology_2018.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/35671
dc.description.abstract The engineering of microbial systems increasingly strives to achieve a co-existence and co-functioning of different populations. By creating interactions, one can utilize combinations of cells where each population has a specialized function, such as regulation or sharing of metabolic burden. Here we describe a microfluidic system that enables long-term and independent growth of fixed and distinctly separate microbial populations, while allowing communication through a thin nano-cellulose filter. Using quorum-sensing signaling, we can couple the populations and show that this leads to a rapid and stable connection over long periods of time. We continue to show that this control over communication can be utilized to drive nonlinear responses. The coupling of separate populations, standardized interaction, and context-independent function lay the foundation for the construction of increasingly complex community-wide dynamic genetic regulatory mechanisms. en
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Communications Biology en
dc.relation.ispartofseries Volume 1 en
dc.rights openAccess en
dc.subject.other 1182 Biochemistry, cell and molecular biology en
dc.title Controlled communication between physically separated bacterial populations in a microfluidic device en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Bioproducts and Biosystems
dc.contributor.department Biomolecular materials
dc.contributor.department Department of Chemistry and Materials Science
dc.contributor.department Microfabrication
dc.contributor.department Department of Materials Science and Engineering en
dc.subject.keyword 1182 Biochemistry, cell and molecular biology
dc.identifier.urn URN:NBN:fi:aalto-201812216680
dc.type.version publishedVersion


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