The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Gasik, Michael
dc.contributor.author Zühlke, Alexandra
dc.contributor.author Haaparanta, Anne-Marie
dc.contributor.author Muhonen, Virpi
dc.contributor.author Laine, Kaisa
dc.contributor.author Bilotsky, Yevgen
dc.contributor.author Kellomäki, Minna
dc.contributor.author Kiviranta, Ilkka
dc.date.accessioned 2018-12-10T10:23:07Z
dc.date.available 2018-12-10T10:23:07Z
dc.date.issued 2018
dc.identifier.citation Gasik , M , Zühlke , A , Haaparanta , A-M , Muhonen , V , Laine , K , Bilotsky , Y , Kellomäki , M & Kiviranta , I 2018 , ' The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration ' FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY . DOI: 10.3389/fbioe.2018.00187 en
dc.identifier.other PURE UUID: 8ad50bf9-cdcd-4e5a-8457-958a4249b0b5
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/the-importance-of-controlled-mismatch-of-biomechanical-compliances-of-implantable-scaffolds-and-native-tissue-for-articular-cartilage-regeneration(8ad50bf9-cdcd-4e5a-8457-958a4249b0b5).html
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/30224685/CHEM_Gasik_et_al_The_importance_of_2018_Frontiers_in_Bioengineering_and_Biotechnology.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/35145
dc.description.abstract Scaffolds for articular cartilage repair have to be optimally biodegradable with simultaneous promotion of hyaline cartilage formation under rather complex biomechanical and physiological conditions. It has been generally accepted that scaffold structure and composition would be the best when it mimics the structure of native cartilage. However, a reparative construct mimicking the mature native tissue in a healing tissue site presents a biological mismatch of reparative stimuli. In this work, we studied a new recombinant human type III collagen-polylactide (rhCol-PLA) scaffolds. The rhCol-PLA scaffolds were assessed for their relative performance in simulated synovial fluids of 1 and 4 mg/mL sodium hyaluronate with application of model-free analysis with Biomaterials Enhanced Simulation Test (BEST). Pure PLA scaffold was used as a control. The BEST results were compared to the results of a prior in vivo study with rhCol-PLA. Collectively the data indicated that a successful articular cartilage repair requirelower stiffness of the scaffold compared to surrounding cartilage yet matching the strain compliance both in static and dynamic conditions. This ensures an optimal combination of load transfer and effective oscillatory nutrients supply to the cells. The results encourage further development of intelligent scaffold structures for optimal articular cartilage repair rather than simply trying to imitate the respective original tissue. en
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation info:eu-repo/grantAgreement/EC/H2020/760921/EU//PANBioRA
dc.relation.ispartofseries FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY en
dc.rights openAccess en
dc.subject.other 216 Materials engineering en
dc.subject.other biomaterials en
dc.title The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Materials Processing and Powder Metallurgy
dc.contributor.department Department of Chemical and Metallurgical Engineering
dc.contributor.department Tampere University of Technology
dc.contributor.department University of Helsinki
dc.contributor.department Seqvera
dc.subject.keyword 216 Materials engineering
dc.subject.keyword biomaterials
dc.identifier.urn URN:NBN:fi:aalto-201812106160
dc.identifier.doi 10.3389/fbioe.2018.00187
dc.type.version publishedVersion


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