Title: | Biologically Inspired High Performance Material - Coacervation of genetically engineered silk-like fusion proteins as an intermediate step toward fabrication of next generation fiber, adhesive and composite |
Author(s): | Mohammadi, Pezhman |
Date: | 2018 |
Language: | en |
Pages: | 52 + app. 50 |
Department: | Biotuotteiden ja biotekniikan laitos Department of Bioproducts and Biosystems |
ISBN: | 978-952-60-8289-9 (electronic) 978-952-60-8288-2 (printed) |
Series: | Aalto University publication series DOCTORAL DISSERTATIONS, 222/2018 |
ISSN: | 1799-4942 (electronic) 1799-4934 (printed) |
Supervising professor(s): | Linder, Markus, Prof., Aalto University, Department of Bioproducts and Biosystems, Finland |
Thesis advisor(s): | Linder, Markus, Prof., Aalto University, Department of Bioproducts and Biosystems, Finland |
Subject: | Biotechnology, Materials science |
Keywords: | genetic engineering, recombinant DNA technology, protein engineering, coacervate, spider silk, fiber, adhesive, nanocomposite, toughness, biomaterial, cellulose |
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Abstract:Nature can serve as a source of inspiration for the design of the next generation high performance materials. Proteins can play a major role in structuring the novel sustainable and advanced functional materials. Given the precise design of proteins at molecular level together with expanding knowledge of new protein sequences, the ease of gene synthesis, cloning strategies and optimized biological production, various potential designs and applications can be anticipated. However, one of the main challenge toward this goal is the lack of understanding of the processes in which such materials could be assembled and form their functional molecular interactions. Inspired by the natural structural material, this thesis highlights solutions to some of the fundamental challenges related to the design strategies and processing routes with the extends the scopes toward potential applications.
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Parts:[Publication 1]: Mohammadi, Pezhman, A. Sesilja Aranko, Laura Lemetti, Zoran Cenev, Quan Zhou, Salla Virtanen, Christopher P. Landowski, Merja Penttilä, Wolfgang J. Fischer, Wolfgang Wagermaier & Markus B. Linder "Phase transitions as intermediate steps in the formation of molecularly engineered protein fibers." Communications Biology 1.1 (2018): 86. Full text in Acris/Aaltodoc: http://urn.fi/URN:NBN:fi:aalto-201809215148 . DOI: 10.1038/s42003-018-0090-y View at Publisher [Publication 2]: Mohammadi, Pezhman, Grégory Beaune, Bjørn Torger Stokke, Jaakko Timonen & Markus B. Linder. “Self-coacervation of a silk-like protein and its use as an adhesive for cellulosic materials." Submitted manuscript the journal of American chemical society ACS Macro Letters in the year 2018. Full text in Acris/Aaltodoc: http://urn.fi/URN:NBN:fi:aalto-201812106254. DOI: 10.1021/acsmacrolett.8b00527 View at Publisher [Publication 3]: Mohammadi, Pezhman, Matti S. Toivonen, Olli Ikkala, Wolfgang Wagermaier & Markus B. Linder "Aligning cellulose nanofibril dispersions for tougher fibers." Scientific Reports 7.1 (2017): 11860. Full text in Acris/Aaltodoc: http://urn.fi/URN:NBN:fi:aalto-201710157214 . DOI: 10.1038/s41598-017-12107-x View at Publisher [Publication 4]: Mohammadi, Pezhman, A Sesilja Aranko, Christopher Paul Landowski, Olli Ikkala, Wolfgang Wagermaier and Markus B Linder “Design and assembly principles for silk-inspired proteins in high-toughness biomimetic nanocellulose composites." Submitted manuscript to the journal of Wiley-VCH Angewandte Chemie International Edition in the year 2018. |
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