High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Selin, Markus
dc.contributor.author Nummelin, Sami
dc.contributor.author Deleu, Jill
dc.contributor.author Ropponen, Jarmo
dc.contributor.author Viitala, Tapani
dc.contributor.author Lahtinen, Manu
dc.contributor.author Koivisto, Jari
dc.contributor.author Hirvonen, Jouni
dc.contributor.author Peltonen, Leena
dc.contributor.author Kostiainen, Mauri A.
dc.contributor.author Bimbo, Luis M.
dc.date.accessioned 2018-10-16T08:55:40Z
dc.date.available 2018-10-16T08:55:40Z
dc.date.issued 2018-08-28
dc.identifier.citation Selin , M , Nummelin , S , Deleu , J , Ropponen , J , Viitala , T , Lahtinen , M , Koivisto , J , Hirvonen , J , Peltonen , L , Kostiainen , M A & Bimbo , L M 2018 , ' High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions ' Biomacromolecules , vol 19 , no. 10 , pp. 3983–3993 . DOI: 10.1021/acs.biomac.8b00931 en
dc.identifier.issn 1525-7797
dc.identifier.issn 1526-4602
dc.identifier.other PURE UUID: 90b3a796-a79c-4a5f-a4c4-1b4e38496a7a
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/highgeneration-amphiphilic-janusdendrimers-as-stabilizing-agents-for-drug-suspensions(90b3a796-a79c-4a5f-a4c4-1b4e38496a7a).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85053596632&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/31661555/High_Generation_Amphiphilic_Janus_Dendrimers_as_Stabilizing_Agents_for_Drug_Suspensions.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/34301
dc.description.abstract Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance the dissolution of poorly water-soluble drug compounds. The stabilizers exert their action through electrostatic or steric interactions, however, the molecular requirements of stabilizing agents have not been studied extensively. Here, four structurally related amphiphilic Janus-dendrimers were synthesized and screened to determine the roles of different macromolecular domains on the stabilization of drug crystals. Physical interaction and nanomilling experiments have substantiated that Janus-dendrimers with fourth generation hydrophilic dendrons were superior to third generation analogues and Poloxamer 188 in stabilizing indomethacin suspensions. Contact angle and surface plasmon resonance measurements support the hypothesis that Janus-dendrimers bind to indomethacin surfaces via hydrophobic interactions and that the number of hydrophobic alkyl tails determines the adsorption kinetics of the Janus-dendrimers. The results showed that amphiphilic Janus-dendrimers adsorb onto drug particles and thus can be used to provide steric stabilization against aggregation and recrystallization. The modular synthetic route for new amphiphilic Janus-dendrimers offers, thus, for the first time a versatile platform for stable general-use stabilizing agents of drug suspensions. en
dc.format.extent 3983–3993
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Biomacromolecules en
dc.relation.ispartofseries Volume 19, issue 10 en
dc.rights openAccess en
dc.subject.other Bioengineering en
dc.subject.other Biomaterials en
dc.subject.other Polymers and Plastics en
dc.subject.other Materials Chemistry en
dc.subject.other 216 Materials engineering en
dc.subject.other 215 Chemical engineering en
dc.title High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department University of Helsinki
dc.contributor.department Department of Bioproducts and Biosystems
dc.contributor.department VTT Technical Research Centre of Finland
dc.contributor.department University of Jyväskylä
dc.contributor.department Department of Chemistry and Materials Science
dc.subject.keyword Bioengineering
dc.subject.keyword Biomaterials
dc.subject.keyword Polymers and Plastics
dc.subject.keyword Materials Chemistry
dc.subject.keyword 216 Materials engineering
dc.subject.keyword 215 Chemical engineering
dc.identifier.urn URN:NBN:fi:aalto-201810165378
dc.identifier.doi 10.1021/acs.biomac.8b00931


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