Polymer ejection from strong spherical confinement

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Piili, Joonas
dc.contributor.author Linna, Riku P.
dc.date.accessioned 2018-08-08T10:03:29Z
dc.date.available 2018-08-08T10:03:29Z
dc.date.issued 2015
dc.identifier.citation Piili , J & Linna , R P 2015 , ' Polymer ejection from strong spherical confinement ' PHYSICAL REVIEW E , vol 92 , no. 6 , 062715 , pp. 1-6 . DOI: 10.1103/PhysRevE.92.062715 en
dc.identifier.issn 1539-3755
dc.identifier.issn 1550-2376
dc.identifier.other PURE UUID: d1ff01c1-0ace-4148-a9cd-e5ee624e797e
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/polymer-ejection-from-strong-spherical-confinement(d1ff01c1-0ace-4148-a9cd-e5ee624e797e).html
dc.identifier.other PURE LINK: http://dx.doi.org/10.1103/PhysRevE.92.062715
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/26800585/PhysRevE.92.062715.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/33114
dc.description VK: Lampinen, J.; TRITON; CSC
dc.description.abstract We examine the ejection of an initially strongly confined flexible polymer from a spherical capsid through a nanoscale pore. We use molecular dynamics for unprecedentedly high initial monomer densities. We show that the time for an individual monomer to eject grows exponentially with the number of ejected monomers. By measurements of the force at the pore we show this dependence to be a consequence of the excess free energy of the polymer due to confinement growing exponentially with the number of monomers initially inside the capsid. This growth relates closely to the divergence of mixing energy in the Flory-Huggins theory at large concentration. We show that the pressure inside the capsid driving the ejection dominates the process that is characterized by the ejection time growing linearly with the lengths of different polymers. Waiting time profiles would indicate that the superlinear dependence obtained for polymers amenable to computer simulations results from a finite-size effect due to the final retraction of polymers' tails from capsids. en
dc.format.extent 1-6
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries PHYSICAL REVIEW E en
dc.relation.ispartofseries Volume 92, issue 6 en
dc.rights openAccess en
dc.title Polymer ejection from strong spherical confinement en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Computer Science en
dc.subject.keyword bacteriophage
dc.subject.keyword capsid ejection
dc.subject.keyword polymer physics
dc.subject.keyword stochastic rotation dynamics
dc.subject.keyword virus capsid
dc.identifier.urn URN:NBN:fi:aalto-201808084514
dc.identifier.doi 10.1103/PhysRevE.92.062715
dc.type.version publishedVersion

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