The effect of the inner-hair-cell mediated transduction on the shape of neural tuning curves

 |  Login

Show simple item record

dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Altoè, Alessandro
dc.contributor.author Pulkki, Ville
dc.contributor.author Verhulst, Sarah
dc.date.accessioned 2018-08-01T12:38:10Z
dc.date.available 2018-08-01T12:38:10Z
dc.date.issued 2018-05-31
dc.identifier.citation Altoè , A , Pulkki , V & Verhulst , S 2018 , The effect of the inner-hair-cell mediated transduction on the shape of neural tuning curves . in To the Ear and Back Again - Advances in Auditory Biophysics : Proceedings of the 13th Mechanics of Hearing Workshop . vol. 1965 , 060003 , AIP Conference Proceedings , vol. 1965 , American Institute of Physics Inc. , International Workshop on the Mechanics of Hearing , St. Catharines , Canada , 19/06/2017 . DOI: 10.1063/1.5038476 en
dc.identifier.isbn 9780735416703
dc.identifier.issn 1935-0465
dc.identifier.other PURE UUID: 10dc11f3-b871-448f-9488-28147c2bf8d6
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/the-effect-of-the-innerhaircell-mediated-transduction-on-the-shape-of-neural-tuning-curves(10dc11f3-b871-448f-9488-28147c2bf8d6).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85048223445&partnerID=8YFLogxK
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/32675
dc.description.abstract The inner hair cells of the mammalian cochlea transform the vibrations of their stereocilia into releases of neurotransmitter at the ribbon synapses, thereby controlling the activity of the afferent auditory fibers. The mechanical-To-neural transduction is a highly nonlinear process and it introduces differences between the frequency-Tuning of the stereocilia and that of the afferent fibers. Using a computational model of the inner hair cell that is based on in vitro data, we estimated that smaller vibrations of the stereocilia are necessary to drive the afferent fibers above threshold at low (≤0.5?kHz) than at high (≥4?kHz) driving frequencies. In the base of the cochlea, the transduction process affects the low-frequency tails of neural tuning curves. In particular, it introduces differences between the frequency-Tuning of the stereocilia and that of the auditory fibers resembling those between basilar membrane velocity and auditory fibers tuning curves in the chinchilla base. For units with a characteristic frequency between 1 and 4?kHz, the transduction process yields shallower neural than stereocilia tuning curves as the characteristic frequency decreases. This study proposes that transduction contributes to the progressive broadening of neural tuning curves from the base to the apex. en
dc.format.extent 7
dc.language.iso en en
dc.relation.ispartof International Workshop on the Mechanics of Hearing en
dc.relation.ispartofseries To the Ear and Back Again - Advances in Auditory Biophysics en
dc.relation.ispartofseries Volume 1965 en
dc.relation.ispartofseries AIP Conference Proceedings en
dc.rights embargoedAccess en
dc.subject.other Physics and Astronomy(all) en
dc.subject.other 3112 Neurosciences en
dc.subject.other 113 Computer and information sciences en
dc.title The effect of the inner-hair-cell mediated transduction on the shape of neural tuning curves en
dc.type A4 Artikkeli konferenssijulkaisussa fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Signal Processing and Acoustics
dc.contributor.department Ghent University
dc.subject.keyword Physics and Astronomy(all)
dc.subject.keyword 3112 Neurosciences
dc.subject.keyword 113 Computer and information sciences
dc.identifier.urn URN:NBN:fi:aalto-201808014075
dc.identifier.doi 10.1063/1.5038476
dc.date.embargo info:eu-repo/date/embargoEnd/2019-06-01


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search archive


Advanced Search

article-iconSubmit a publication

Browse

My Account