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Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Sipponen, Mika Henrikki
dc.contributor.author Farooq, Muhammad
dc.contributor.author Koivisto, Jari
dc.contributor.author Pellis, Alessandro
dc.contributor.author Seitsonen, Jani
dc.contributor.author Österberg, Monika
dc.date.accessioned 2018-06-29T12:49:47Z
dc.date.available 2018-06-29T12:49:47Z
dc.date.issued 2018-12-01
dc.identifier.citation Sipponen , M H , Farooq , M , Koivisto , J , Pellis , A , Seitsonen , J & Österberg , M 2018 , ' Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media ' , Nature Communications , vol. 9 , no. 1 , 2300 . https://doi.org/10.1038/s41467-018-04715-6 en
dc.identifier.issn 2041-1723
dc.identifier.other PURE UUID: bfde67ea-4fba-4940-a6ff-22e1a572fdb9
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/bfde67ea-4fba-4940-a6ff-22e1a572fdb9
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85048370996&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/26025556/Sipponen_et_al_Spatially_confined_2018_Nature_Communications.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/32614
dc.description.abstract Dehydration reactions proceed readily in water-filled biological cells. Development of biocatalysts that mimic such compartmentalized reactions has been cumbersome due to the lack of low-cost nanomaterials and associated technologies. Here we show that cationic lignin nanospheres function as activating anchors for hydrolases, and enable aqueous ester synthesis by forming spatially confined biocatalysts upon self-assembly and drying-driven aggregation in calcium alginate hydrogel. Spatially confined microbial cutinase and lipase retain 97% and 70% of their respective synthetic activities when the volume ratio of water to hexane increases from 1:1 to 9:1 in the reaction medium. The activity retention of industrially most frequently used acrylic resin-immobilized Candida antarctica lipase B is only 51% under similar test conditions. Overall, our findings enable fabrication of robust renewable biocatalysts for aqueous ester synthesis, and provide insight into the compartmentalization of diverse heterogeneous catalysts. en
dc.format.extent 7
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries Nature Communications en
dc.relation.ispartofseries Volume 9, issue 1 en
dc.rights openAccess en
dc.title Spatially confined lignin nanospheres for biocatalytic ester synthesis in aqueous media en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Bioproducts and Biosystems
dc.contributor.department Department of Chemistry and Materials Science
dc.contributor.department University of York
dc.contributor.department Department of Applied Physics
dc.identifier.urn URN:NBN:fi:aalto-201806294024
dc.identifier.doi 10.1038/s41467-018-04715-6
dc.type.version publishedVersion

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