Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Laurén, Patrick Somersalo, Petter Pitkänen, Irina Lou, Yan Ru Urtti, Arto Partanen, Jouni Seppälä, Jukka Madetoja, Mari Laaksonen, Timo Mäkitie, Antti Yliperttula, Marjo 2018-06-18T09:20:48Z 2018-06-18T09:20:48Z 2017-08-01
dc.identifier.citation Laurén , P , Somersalo , P , Pitkänen , I , Lou , Y R , Urtti , A , Partanen , J , Seppälä , J , Madetoja , M , Laaksonen , T , Mäkitie , A & Yliperttula , M 2017 , ' Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems ' PLOS ONE , vol 12 , no. 8 , e0183487 . DOI: 10.1371/journal.pone.0183487 en
dc.identifier.issn 1932-6203
dc.identifier.other PURE UUID: a9af3c3c-02cc-4824-ac1a-a422537c8cf3
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dc.description Seppälän osalta väärä affiliaatio. Kerrottu Jukalle. Kokotekstiä ei pystynyt tallentamaan PLOSilta.
dc.description.abstract Hydrogel nanomaterials, especially those that are of non-human and non-animal origins, have great potential in biomedical and pharmaceutical sciences due to their versatility and inherent soft-tissue like properties. With the ability to simulate native tissue function, hydrogels are potentially well suited for cellular therapy applications. In this study, we have fabricated nanofibrillar cellulose-alginate (NFCA) suture coatings as biomedical devices to help overcome some of the limitations related to cellular therapy, such as low cell survivability and distribution out of target tissue. The addition of sodium alginate 8% (w/v) increased the NFCA hydrogel viscosity, storage and loss moduli by slightly under one order of magnitude, thus contributing significantly to coating strength. Confocal microscopy showed nearly 100% cell viability throughout the 2-week incubation period within and on the surface of the coating. Additionally, typical morphologies in the dual cell culture of spheroid forming HepG2 and monolayer type SK-HEP-1 were observed. Twelve out of 14 NFCA coated surgical sutures remained intact during the suturing operation with various mice and rat tissue; however, partial peeling off was observed in 2 of the coated sutures. We conclude that NFCA suture coatings could perform as cell-carrier systems for cellular based therapy and post-surgical treatment. en
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries PLOS ONE en
dc.relation.ispartofseries Volume 12, issue 8 en
dc.rights openAccess en
dc.subject.other Medicine(all) en
dc.subject.other Biochemistry, Genetics and Molecular Biology(all) en
dc.subject.other Agricultural and Biological Sciences(all) en
dc.subject.other 214 Mechanical engineering en
dc.title Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department University of Helsinki
dc.contributor.department Aalto University
dc.contributor.department Department of Mechanical Engineering
dc.contributor.department Department of Chemical and Metallurgical Engineering
dc.contributor.department Made Consulting Ltd Oy
dc.subject.keyword Medicine(all)
dc.subject.keyword Biochemistry, Genetics and Molecular Biology(all)
dc.subject.keyword Agricultural and Biological Sciences(all)
dc.subject.keyword 214 Mechanical engineering
dc.identifier.urn URN:NBN:fi:aalto-201806183356
dc.identifier.doi 10.1371/journal.pone.0183487
dc.type.version publishedVersion

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