Superhydrophobic blood-repellent surfaces

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Jokinen, Ville
dc.contributor.author Kankuri, Esko
dc.contributor.author Hoshian, Sasha
dc.contributor.author Franssila, Sami
dc.contributor.author Ras, Robin
dc.date.accessioned 2018-05-22T14:36:22Z
dc.date.available 2018-05-22T14:36:22Z
dc.date.issued 2018-06
dc.identifier.citation Jokinen , V , Kankuri , E , Hoshian , S , Franssila , S & Ras , R 2018 , ' Superhydrophobic blood-repellent surfaces ' , Advanced Materials , vol. 30 , no. 24 , 1705104 . https://doi.org/10.1002/adma.201705104 en
dc.identifier.issn 0935-9648
dc.identifier.issn 1521-4095
dc.identifier.other PURE UUID: 56a7db51-42e3-4943-ba91-28bc847ab908
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/superhydrophobic-bloodrepellent-surfaces(56a7db51-42e3-4943-ba91-28bc847ab908).html
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/19769492/Jokinen_et_al_2017_Advanced_Materials.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/30913
dc.description | openaire: EC/H2020/725513/EU//SuperRepel
dc.description.abstract Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted. en
dc.format.extent 10
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation info:eu-repo/grantAgreement/EC/H2020/725513/EU//SuperRepel
dc.relation.ispartofseries ADVANCED MATERIALS en
dc.relation.ispartofseries articlenumber 1705104 en
dc.rights openAccess en
dc.subject.other 216 Materials engineering en
dc.title Superhydrophobic blood-repellent surfaces en
dc.type A2 Katsausartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Chemistry and Materials Science
dc.contributor.department University of Helsinki
dc.contributor.department Microfabrication
dc.contributor.department Department of Applied Physics
dc.contributor.department Department of Bioproducts and Biosystems en
dc.subject.keyword antithrombogenic
dc.subject.keyword blood-compatible
dc.subject.keyword blood-repellent
dc.subject.keyword nanostructures
dc.subject.keyword superhydrophobic
dc.subject.keyword 216 Materials engineering
dc.identifier.urn URN:NBN:fi:aalto-201805222353
dc.identifier.doi 10.1002/adma.201705104
dc.type.version publishedVersion


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