Synthesis and characterization of cellulose-derived polymers for the treatment of damaged cartilage

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.advisor Valle-Delgado, Juan José Han, Mingyu 2017-07-04T06:26:46Z 2017-07-04T06:26:46Z 2017-06-13
dc.description.abstract Carboxymethyl cellulose (CMC) is currently the most widely used cellulose derivative and considered as a promising biomaterial due to its biocompatibility, biodegradability and non-toxicity. Polyethylene glycol grafted carboxymethyl cellulose (CMC-g-PEG) has been proved to be a very lubricating polymer. This MSc. thesis work aims to study further the potential application of the lubricating CMC-g-PEG for the treatment of damaged cartilage. CMC-g-PEG with different PEG chain lengths were successfully synthesized and characterized by conductometric titration and Fourier transform infrared spectroscopy. Polyethylene glycol grafted dialdehyde carboxymethyl cellulose (DCMC-g-PEG) was synthesized by oxidation of CMC-g-PEG with sodium periodate. The adsorption of the different polymers on collagen IV films (first approach model for cartilage) was studied by quartz crystal microbalance with dissipation. Compared with dialyzed CMC and CMC-g-PEG, much more DCMC-g-PEG absorbed onto the surface of collagen IV films due to the existence of covalently binding between aldehyde groups of DCMC-g-PEG and amine groups of collagens. The adsorption results of CMC-g-PEG and DCMC-g-PEG provide the evidence that the introduction of aldehyde groups to the backbone of CMC-g-PEG can improve its attaching ability to collagen IV. en
dc.format.extent 61+4
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.title Synthesis and characterization of cellulose-derived polymers for the treatment of damaged cartilage en
dc.type G2 Pro gradu, diplomityö fi Kemian tekniikan korkeakoulu fi
dc.subject.keyword CMC en
dc.subject.keyword CMC-g-PEG en
dc.subject.keyword DCMC-g-PEG en
dc.subject.keyword osteoarthritis en
dc.subject.keyword cartilage en
dc.subject.keyword attaching ability en
dc.identifier.urn URN:NBN:fi:aalto-201707045926
dc.programme.major Biomaterials Science fi
dc.programme.mcode CHEM3041 fi
dc.type.ontasot Master's thesis en
dc.type.ontasot Diplomityö fi
dc.contributor.supervisor Österberg, Monika
dc.programme Nordic Master Program in Polymer Technology fi
dc.ethesisid Aalto 9452
dc.location P1 fi

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