Cyclic Alternating Pattern Is Associated with Cerebral Hemodynamic Variation: A Near-Infrared Spectroscopy Study of Sleep in Healthy Humans

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Näsi, Tiina
dc.contributor.author Virtanen, Jaakko
dc.contributor.author Toppila, Jussi
dc.contributor.author Salmi, Tapani
dc.contributor.author Ilmoniemi, Risto J.
dc.date.accessioned 2017-05-11T09:16:32Z
dc.date.available 2017-05-11T09:16:32Z
dc.date.issued 2012
dc.identifier.citation Näsi , T , Virtanen , J , Toppila , J , Salmi , T & Ilmoniemi , R J 2012 , ' Cyclic Alternating Pattern Is Associated with Cerebral Hemodynamic Variation: A Near-Infrared Spectroscopy Study of Sleep in Healthy Humans ' PLOS ONE , vol 7 , no. 10 , e46899 , pp. 1-8 . DOI: 10.1371/journal.pone.0046899 en
dc.identifier.issn 1932-6203
dc.identifier.other PURE UUID: fc73d69b-61d6-4413-80d6-0d5c75b9bacc
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/cyclic-alternating-pattern-is-associated-with-cerebral-hemodynamic-variation-a-nearinfrared-spectroscopy-study-of-sleep-in-healthy-humans(fc73d69b-61d6-4413-80d6-0d5c75b9bacc).html
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/12866254/journal.pone.0046899.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/25994
dc.description.abstract The cyclic alternating pattern (CAP), that is, cyclic variation of brain activity within non-REM sleep stages, is related to sleep instability and preservation, as well as consolidation of learning. Unlike the well-known electrical activity of CAP, its cerebral hemodynamic counterpart has not been assessed in healthy subjects so far. We recorded scalp and cortical hemodynamics with near-infrared spectroscopy on the forehead and systemic hemodynamics (heart rate and amplitude of the photoplethysmograph) with a finger pulse oximeter during 23 nights in 11 subjects. Electrical CAP activity was recorded with a polysomnogram. CAP was related to changes in scalp, cortical, and systemic hemodynamic signals that resembled the ones seen in arousal. Due to their repetitive nature, CAP sequences manifested as low- and very-low-frequency oscillations in the hemodynamic signals. The subtype A3+B showed the strongest hemodynamic changes. A transient hypoxia occurred during CAP cycles, suggesting that an increased CAP rate,especially with the subtype A3+B, which may result from diseases or fragmented sleep, might have an adverse effect on the cerebral vasculature. en
dc.format.extent 1-8
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries PLOS ONE en
dc.relation.ispartofseries Volume 7, issue 10 en
dc.rights openAccess en
dc.title Cyclic Alternating Pattern Is Associated with Cerebral Hemodynamic Variation: A Near-Infrared Spectroscopy Study of Sleep in Healthy Humans en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.identifier.urn URN:NBN:fi:aalto-201705114369
dc.identifier.doi 10.1371/journal.pone.0046899
dc.type.version publishedVersion


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