Parietal lobe critically supports successful paired immediate and single-item delayed memory for targets

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Krumm, Sabine Kivisaari, Sasa L. Monsch, Andreas U. Reinhardt, Julia Ulmer, Stephan Stippich, Christoph Kressig, Reto W. Taylor, Kirsten I. 2017-05-11T09:10:43Z 2017-05-11T09:10:43Z 2017-05-01
dc.identifier.citation Krumm , S , Kivisaari , S L , Monsch , A U , Reinhardt , J , Ulmer , S , Stippich , C , Kressig , R W & Taylor , K I 2017 , ' Parietal lobe critically supports successful paired immediate and single-item delayed memory for targets ' NEUROBIOLOGY OF LEARNING AND MEMORY , vol 141 , pp. 53-59 . DOI: 10.1016/j.nlm.2017.03.016 en
dc.identifier.issn 1074-7427
dc.identifier.other PURE UUID: e6f8e50c-5cd8-48bf-8afb-19f8eb66a304
dc.identifier.other PURE ITEMURL:
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dc.description.abstract The parietal lobe is important for successful recognition memory, but its role is not yet fully understood. We investigated the parietal lobes’ contribution to immediate paired-associate memory and delayed item-recognition memory separately for hits (targets) and correct rejections (distractors). We compared the behavioral performance of 56 patients with known parietal and medial temporal lobe dysfunction (i.e. early Alzheimer's Disease) to 56 healthy control participants in an immediate paired and delayed single item object memory task. Additionally, we performed voxel-based morphometry analyses to investigate the functional-neuroanatomic relationships between performance and voxel-based estimates of atrophy in whole-brain analyses. Behaviorally, all participants performed better identifying targets than rejecting distractors. The voxel-based morphometry analyses associated atrophy in the right ventral parietal cortex with fewer correct responses to familiar items (i.e. hits) in the immediate and delayed conditions. Additionally, medial temporal lobe integrity correlated with better performance in rejecting distractors, but not in identifying targets, in the immediate paired-associate task. Our findings suggest that the parietal lobe critically supports successful immediate and delayed target recognition memory, and that the ventral aspect of the parietal cortex and the medial temporal lobe may have complementary preferences for identifying targets and rejecting distractors, respectively, during recognition memory. en
dc.format.extent 7
dc.format.extent 53-59
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries NEUROBIOLOGY OF LEARNING AND MEMORY en
dc.relation.ispartofseries Volume 141 en
dc.rights openAccess en
dc.subject.other Experimental and Cognitive Psychology en
dc.subject.other Cognitive Neuroscience en
dc.subject.other Behavioral Neuroscience en
dc.subject.other 3112 Neurosciences en
dc.title Parietal lobe critically supports successful paired immediate and single-item delayed memory for targets en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Felix-Platter Hospital
dc.contributor.department Department of Neuroscience and Biomedical Engineering
dc.contributor.department University of Basel
dc.contributor.department Medical Radiological Institute (MRI)
dc.contributor.department University of Cambridge
dc.subject.keyword Alzheimers’ dementia
dc.subject.keyword Atrophy
dc.subject.keyword Parietal lobe
dc.subject.keyword Recognition memory
dc.subject.keyword Voxel-based morphometry
dc.subject.keyword Experimental and Cognitive Psychology
dc.subject.keyword Cognitive Neuroscience
dc.subject.keyword Behavioral Neuroscience
dc.subject.keyword 3112 Neurosciences
dc.identifier.urn URN:NBN:fi:aalto-201705114303
dc.identifier.doi 10.1016/j.nlm.2017.03.016
dc.type.version publishedVersion

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