Silica-gentamicin nanohybrids

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Ahmed Mosselhy, Dina Ge, Yanling Gasik, Michael Nordström, Katrina Natri, Olli Hannula, Simo-Pekka 2017-05-11T09:06:37Z 2017-05-11T09:06:37Z 2016
dc.identifier.citation Ahmed Mosselhy , D , Ge , Y , Gasik , M , Nordström , K , Natri , O & Hannula , S-P 2016 , ' Silica-gentamicin nanohybrids : Synthesis and antimicrobial action ' MATERIALS , vol 9 , no. 3 , 170 . DOI: 10.3390/ma9030170 en
dc.identifier.issn 1996-1944
dc.identifier.other PURE UUID: c3ecaee6-c117-4234-a77f-6b7096328f43
dc.identifier.other PURE ITEMURL:
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dc.description.abstract Orthopedic applications commonly require the administration of systemic antibiotics. Gentamicin is one of the most commonly used aminoglycosides in the treatment and prophylaxis of infections associated with orthopedic applications, but gentamicin has a short half-life. However, silica nanoparticles (SiO2 NPs) can be used as elegant carriers for antibiotics to prolong their release. Our goal is the preparation and characterization of SiO2-gentamicin nanohybrids for their potential antimicrobial administration in orthopedic applications. In vitro gentamicin release profile from the nanohybrids (gentamicin-conjugated SiO2 NPs) prepared by the base-catalyzed precipitation exhibited fast release (21.4%) during the first 24 h and further extension with 43.9% release during the five-day experiment. Antimicrobial studies of the SiO2-gentamicin nanohybrids versus native SiO2 NPs and free gentamicin were performed against Bacillus subtilis (B. subtilis), Pseudomonas fluorescens (P. fluorescens) and Escherichia coli (E. coli). SiO2-gentamicin nanohybrids were most effective against B. subtilis. SiO2 NPs play no antimicrobial role. Parallel antimicrobial studies for the filter-sterilized gentamicin were performed to assess the effect of ultraviolet (UV)-irradiation on gentamicin. In summary, the initial fast gentamicin release fits the need for high concentration of antibiotics after orthopedic surgical interventions. Moreover, the extended release justifies the promising antimicrobial administration of the nanohybrids in bone applications. en
dc.format.extent 16
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries MATERIALS en
dc.relation.ispartofseries Volume 9, issue 3 en
dc.rights openAccess en
dc.subject.other Materials Science(all) en
dc.subject.other 221 Nanotechnology en
dc.title Silica-gentamicin nanohybrids en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Materials Science and Engineering
dc.contributor.department Department of Biotechnology and Chemical Technology
dc.contributor.department Department of Chemistry and Materials Science en
dc.contributor.department Department of Chemical and Metallurgical Engineering en
dc.contributor.department Department of Bioproducts and Biosystems en
dc.subject.keyword Antimicrobial effect
dc.subject.keyword Gentamicin
dc.subject.keyword In vitro release
dc.subject.keyword Orthopedic applications
dc.subject.keyword Silica nanoparticles
dc.subject.keyword Materials Science(all)
dc.subject.keyword 221 Nanotechnology
dc.identifier.urn URN:NBN:fi:aalto-201705114212
dc.identifier.doi 10.3390/ma9030170
dc.type.version publishedVersion

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