Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Rojalin, Tatu
dc.contributor.author Kurki, Lauri
dc.contributor.author Laaksonen, Timo
dc.contributor.author Viitala, Tapani
dc.contributor.author Kostamovaara, Juha
dc.contributor.author Gordon, Keith C.
dc.contributor.author Galvis Rojas, Leonardo
dc.contributor.author Wachsmann-Hogiu, Sebastian
dc.contributor.author Strachan, Clare J.
dc.contributor.author Yliperttula, Marjo
dc.date.accessioned 2017-05-11T09:05:44Z
dc.date.available 2017-05-11T09:05:44Z
dc.date.issued 2016
dc.identifier.citation Rojalin , T , Kurki , L , Laaksonen , T , Viitala , T , Kostamovaara , J , Gordon , K C , Galvis Rojas , L , Wachsmann-Hogiu , S , Strachan , C J & Yliperttula , M 2016 , ' Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector ' ANALYTICAL AND BIOANALYTICAL CHEMISTRY , vol 408 , no. 3 , pp. 761-774 . DOI: 10.1007/s00216-015-9156-6 en
dc.identifier.issn 1618-2642
dc.identifier.issn 1618-2650
dc.identifier.other PURE UUID: bce6ba14-9781-431e-a091-7d6d08ba49d9
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/fluorescencesuppressed-timeresolved-raman-spectroscopy-of-pharmaceuticals-using-complementary-metaloxide-semiconductor-cmos-singlephoton-avalanche-diode-spad-detector(bce6ba14-9781-431e-a091-7d6d08ba49d9).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=84955186349&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/11454709/Rajalin_et_al_2016_Fluorescence_suppressed_time_resolved.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/25825
dc.description.abstract In this work, we utilize a short-wavelength, 532-nm picosecond pulsed laser coupled with a time-gated complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector to acquire Raman spectra of several drugs of interest. With this approach, we are able to reveal previously unseen Raman features and suppress the fluorescence background of these drugs. Compared to traditional Raman setups, the present time-resolved technique has two major improvements. First, it is possible to overcome the strong fluorescence background that usually interferes with the much weaker Raman spectra. Second, using the high photon energy excitation light source, we are able to generate a stronger Raman signal compared to traditional instruments. In addition, observations in the time domain can be performed, thus enabling new capabilities in the field of Raman and fluorescence spectroscopy. With this system, we demonstrate for the first time the possibility of recording fluorescence-suppressed Raman spectra of solid, amorphous and crystalline, and non-photoluminescent and photoluminescent drugs such as caffeine, ranitidine hydrochloride, and indomethacin (amorphous and crystalline forms). The raw data acquired by utilizing only the picosecond pulsed laser and a CMOS SPAD detector could be used for identifying the compounds directly without any data processing. Moreover, to validate the accuracy of this time-resolved technique, we present density functional theory (DFT) calculations for a widely used gastric acid inhibitor, ranitidine hydrochloride. The obtained time-resolved Raman peaks were identified based on the calculations and existing literature. Raman spectra using non-time-resolved setups with continuous-wave 785- and 532-nm excitation lasers were used as reference data. Overall, this demonstration of time-resolved Raman and fluorescence measurements with a CMOS SPAD detector shows promise in diverse areas, including fundamental chemical research, the pharmaceutical setting, process analytical technology (PAT), and the life sciences. en
dc.format.extent 14
dc.format.extent 761-774
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries ANALYTICAL AND BIOANALYTICAL CHEMISTRY en
dc.relation.ispartofseries Volume 408, issue 3 en
dc.rights openAccess en
dc.subject.other Analytical Chemistry en
dc.subject.other Biochemistry en
dc.subject.other 215 Chemical engineering en
dc.title Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department University of California
dc.contributor.department University of Oulu
dc.contributor.department University of Helsinki
dc.contributor.department University of Otago
dc.contributor.department Department of Forest Products Technology
dc.subject.keyword CMOS SPAD
dc.subject.keyword Fluorescence suppression
dc.subject.keyword Pharmaceuticals
dc.subject.keyword Process analytical technology (PAT)
dc.subject.keyword Raman
dc.subject.keyword Time resolved
dc.subject.keyword Analytical Chemistry
dc.subject.keyword Biochemistry
dc.subject.keyword 215 Chemical engineering
dc.identifier.urn URN:NBN:fi:aalto-201705114200
dc.identifier.doi 10.1007/s00216-015-9156-6
dc.type.version publishedVersion


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