Preserved Coupling between the Reader's Voice and the Listener's Cortical Activity in Autism Spectrum Disorders

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Clumeck, Catherine Garcia, Sarah Suarez Bourguignon, Mathieu Wens, Vincent Op de Beeck, Marc Marty, Brice Deconinck, Nicolas Soncarrieu, Marie-Vincianne Goldman, Serge Jousmaki, Veikko Van Bogaert, Patrick De Tiege, Xavier 2017-05-11T09:03:16Z 2017-05-11T09:03:16Z 2014
dc.identifier.citation Clumeck , C , Garcia , S S , Bourguignon , M , Wens , V , Op de Beeck , M , Marty , B , Deconinck , N , Soncarrieu , M-V , Goldman , S , Jousmaki , V , Van Bogaert , P & De Tiege , X 2014 , ' Preserved Coupling between the Reader's Voice and the Listener's Cortical Activity in Autism Spectrum Disorders ' PLOS ONE , vol 9 , no. 3 , e92329 , pp. 1-8 . DOI: 10.1371/journal.pone.0092329 en
dc.identifier.issn 1932-6203
dc.identifier.other PURE UUID: a872dedf-1380-4432-857c-c877e5b35e54
dc.identifier.other PURE ITEMURL:
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dc.description.abstract Purpose Investigating the steadiness of the phase-coupling between the time-course of the reader's voice and brain signals of subjects with autism spectrum disorder (ASD) passively listening to connected speech using magnetoencephalography (MEG). In typically developed subjects, such coupling occurs at the right posterior temporal sulcus (pSTS) for frequencies below 1 Hz, and reflects the neural processing of sentence-level rhythmic prosody at the prelexical level. Methods Cortical neuromagnetic signals were recorded with MEG (Elekta Oy, Finland) while seven right-handed and native French-speaking ASD subjects (six males, one female, range: 13–20 years) listened to live (Live) or recorded (Recorded) voices continuously reading a text in French for five minutes. Coherence was computed between the reader's voice time-course and ASD subjects' MEG signals. Coherent neural sources were subsequently reconstructed using a beamformer. Key findings Significant coupling was found at 0.5 Hz in all ASD subjects in Live and in six subjects in Recorded. Coherent sources were located close to the right pSTS in both conditions. No significant difference was found in coherence levels between Live and Recorded, and between ASD subjects and ten typically developed subjects (right-handed, native French-speaking adults, 5 males, 5 females, age range: 21–38 years) included in a previous study. Significance This study discloses a preserved coupling between the reader's voice and ASD subjects' cortical activity at the right pSTS. These findings support the existence of preserved neural processing of sentence-level rhythmic prosody in ASD. The preservation of early cortical processing of prosodic elements in verbal language might be exploited in therapeutic interventions in ASD. en
dc.format.extent 1-8
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries PLOS ONE en
dc.relation.ispartofseries Volume 9, issue 3 en
dc.rights openAccess en
dc.subject.other 114 Physical sciences en
dc.subject.other 221 Nanotechnology en
dc.subject.other 214 Mechanical engineering en
dc.subject.other 218 Environmental engineering en
dc.title Preserved Coupling between the Reader's Voice and the Listener's Cortical Activity in Autism Spectrum Disorders en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Neuroscience and Biomedical Engineering en
dc.subject.keyword 114 Physical sciences
dc.subject.keyword 221 Nanotechnology
dc.subject.keyword 214 Mechanical engineering
dc.subject.keyword 218 Environmental engineering
dc.identifier.urn URN:NBN:fi:aalto-201705114151
dc.identifier.doi 10.1371/journal.pone.0092329
dc.type.version publishedVersion

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