Autism spectrum traits predict the neural response to eye gaze in typical individuals

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Nummenmaa, Lauri
dc.contributor.author Engell, Andrew D.
dc.contributor.author von dem Hagen, Elisabeth
dc.contributor.author Henson, Richard N.A
dc.contributor.author Calder, Andrew J.
dc.date.accessioned 2017-05-03T12:24:32Z
dc.date.available 2017-05-03T12:24:32Z
dc.date.issued 2012
dc.identifier.citation Nummenmaa , L , Engell , A D , von dem Hagen , E , Henson , R N A & Calder , A J 2012 , ' Autism spectrum traits predict the neural response to eye gaze in typical individuals ' NEUROIMAGE , vol 59 , no. 4 , pp. 3356-3363 . DOI: 10.1016/j.neuroimage.2011.10.075 en
dc.identifier.issn 1053-8119
dc.identifier.issn 1095-9572
dc.identifier.other PURE UUID: 47a33abe-6999-4a17-90a2-d3e68cddbd71
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/autism-spectrum-traits-predict-the-neural-response-to-eye-gaze-in-typical-individuals(47a33abe-6999-4a17-90a2-d3e68cddbd71).html
dc.identifier.other PURE LINK: http://dx.doi.org/10.1016/j.neuroimage.2011.10.075
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/11777987/1_s2.0_S1053811911012390_main.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/25394
dc.description.abstract Autism Spectrum Disorders (ASD) are neurodevelopmental disorders characterised by impaired social interaction and communication, restricted interests and repetitive behaviours. The severity of these characteristics are posited to lie on a continuum extending into the typical population, and typical adults' performance on behavioural tasks that are impaired in ASD is correlated with the extent to which they display autistic traits (as measured by Autism Spectrum Quotient, AQ). Individuals with ASD also show structural and functional differences in brain regions involved in social perception. Here we show that variation in AQ in typically developing individuals is associated with altered brain activity in the neural circuit for social attention perception while viewing others' eye gaze. In an fMRI experiment, participants viewed faces looking at variable or constant directions. In control conditions, only the eye region was presented or the heads were shown with eyes closed but oriented at variable or constant directions. The response to faces with variable vs. constant eye gaze direction was associated with AQ scores in a number of regions (posterior superior temporal sulcus, intraparietal sulcus, temporoparietal junction, amygdala, and MT/V5) of the brain network for social attention perception. No such effect was observed for heads with eyes closed or when only the eyes were presented. The results demonstrate a relationship between neurophysiology and autism spectrum traits in the typical (non-ASD) population and suggest that changes in the functioning of the neural circuit for social attention perception is associated with an extended autism spectrum in the typical population. en
dc.format.extent 3356-3363
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries NEUROIMAGE en
dc.relation.ispartofseries Volume 59, issue 4 en
dc.rights openAccess en
dc.subject.other 114 Physical sciences en
dc.subject.other 221 Nanotechnology en
dc.subject.other 214 Mechanical engineering en
dc.subject.other 218 Environmental engineering en
dc.title Autism spectrum traits predict the neural response to eye gaze in typical individuals en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Neuroscience and Biomedical Engineering en
dc.subject.keyword Eye gaze
dc.subject.keyword fMRI
dc.subject.keyword Autism spectrum
dc.subject.keyword Attention
dc.subject.keyword Face perception
dc.subject.keyword 114 Physical sciences
dc.subject.keyword 221 Nanotechnology
dc.subject.keyword 214 Mechanical engineering
dc.subject.keyword 218 Environmental engineering
dc.identifier.urn URN:NBN:fi:aalto-201705033795
dc.identifier.doi 10.1016/j.neuroimage.2011.10.075
dc.type.version publishedVersion


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