Hybrid membrane biomaterials from self-assembly in polysaccharide and peptide amphiphile mixtures

 |  Login

Show simple item record

dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Castelletto, V.
dc.contributor.author Kaur, A.
dc.contributor.author Hamley, I. W.
dc.contributor.author Barnes, R. H.
dc.contributor.author Karatzas, K. A.
dc.contributor.author Hermida-Merino, D.
dc.contributor.author Swioklo, S.
dc.contributor.author Connon, C. J.
dc.contributor.author Stasiak, J.
dc.contributor.author Reza, M.
dc.contributor.author Ruokolainen, J.
dc.date.accessioned 2017-05-03T12:00:34Z
dc.date.available 2017-05-03T12:00:34Z
dc.date.issued 2017
dc.identifier.citation Castelletto , V , Kaur , A , Hamley , I W , Barnes , R H , Karatzas , K A , Hermida-Merino , D , Swioklo , S , Connon , C J , Stasiak , J , Reza , M & Ruokolainen , J 2017 , ' Hybrid membrane biomaterials from self-assembly in polysaccharide and peptide amphiphile mixtures : controllable structural and mechanical properties and antimicrobial activity ' RSC ADVANCES , vol 7 , no. 14 , pp. 8366-8375 . DOI: 10.1039/c6ra27244d en
dc.identifier.issn 2046-2069
dc.identifier.other PURE UUID: 3ac66a4c-792c-436b-9690-e0d1ed17b63b
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/hybrid-membrane-biomaterials-from-selfassembly-in-polysaccharide-and-peptide-amphiphile-mixtures(3ac66a4c-792c-436b-9690-e0d1ed17b63b).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85011025155&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/19281804/Castelletto_et_a_2018_Hybrid_membrane_biomaterials_RSC_advances.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/25365
dc.description.abstract Macroscopic capsules, with tunable properties based on hierarchical self-assembly on multiple lengthscales, are prepared from the co-operative self-assembly of polysaccharide and peptide amphiphiles. Different formulations can be used to create flexible membrane sacs in solution, soft capsules or rigid free-standing capsules. Samples are prepared by injecting a solution containing sodium alginate, with or without graphene oxide (GO), into a matrix consisting of a solution containing the peptide amphiphile PA C16-KKFF (K: lysine, F: phenylalanine), with or without CaCl2. Graphene oxide is added to the hybrid materials to modulate the mechanical properties of the capsules. Injection of sodium alginate solution into a pure PA matrix provides a flexible membrane sac in solution, while injection of NaAlg/GO solution into a PA matrix gives a soft capsule. Alternatively, a rigid free-standing capsule is made by injecting a NaAlg/GO solution into a PA + CaCl2 matrix solution. A comprehensive insight into the hierarchical order within the capsules is provided through analysis of X-ray scattering data. A novel “Langmuir-Blodgett” mechanism is proposed to account for the formation of the sacs and capsules as the alginate solution is injected at the interface of the PA solution. The capsules show a unique antibacterial effect specific for the Gram positive bacterium Listeria monocytogenes, which is an important human pathogen. The hybrid nanostructured capsules thus have remarkable bioactivity and due to their tunable structural and functional properties are likely to have a diversity of other future applications. en
dc.format.extent 10
dc.format.extent 8366-8375
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries RSC ADVANCES en
dc.relation.ispartofseries Volume 7, issue 14 en
dc.rights openAccess en
dc.subject.other Chemistry(all) en
dc.subject.other Chemical Engineering(all) en
dc.subject.other 114 Physical sciences en
dc.title Hybrid membrane biomaterials from self-assembly in polysaccharide and peptide amphiphile mixtures en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department University of Reading
dc.contributor.department ESRF-The European Synchrotron
dc.contributor.department Newcastle University Business School
dc.contributor.department University of Cambridge
dc.contributor.department Department of Applied Physics
dc.subject.keyword Chemistry(all)
dc.subject.keyword Chemical Engineering(all)
dc.subject.keyword 114 Physical sciences
dc.identifier.urn URN:NBN:fi:aalto-201705033766
dc.identifier.doi 10.1039/c6ra27244d
dc.type.version proof

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search archive

Advanced Search

article-iconSubmit a publication


My Account