Standard of hygiene and immune adaptation in newborn infants

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Kallionpää, Henna Laajala, Essi Öling, Viveka Härkönen, Taina Tillmann, Vallo Dorshakova, Natalya V. Ilonen, Jorma Lähdesmäki, Harri Knip, Mikael Lahesmaa, Riitta 2017-04-28T09:58:20Z 2017-04-28T09:58:20Z 2014
dc.identifier.citation Kallionpää , H , Laajala , E , Öling , V , Härkönen , T , Tillmann , V , Dorshakova , N V , Ilonen , J , Lähdesmäki , H , Knip , M & Lahesmaa , R 2014 , ' Standard of hygiene and immune adaptation in newborn infants ' CLINICAL IMMUNOLOGY , vol 155 , no. 1 , pp. 136-147 . DOI: 10.1016/j.clim.2014.09.009 en
dc.identifier.issn 1521-6616
dc.identifier.other PURE UUID: 1e3c16d1-c5fa-4cf8-ad91-7e7e5207d9cf
dc.identifier.other PURE ITEMURL:
dc.identifier.other PURE FILEURL:
dc.description VK: symmys
dc.description.abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu. en
dc.format.extent 136-147
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries CLINICAL IMMUNOLOGY en
dc.relation.ispartofseries Volume 155, issue 1 en
dc.rights openAccess en
dc.title Standard of hygiene and immune adaptation in newborn infants en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Tietojenkäsittelytieteen laito
dc.contributor.department Centre of Excellence in Molecular Systems Immunology and Physiology Research Group, SyMMys
dc.subject.keyword Hygiene hypothesis
dc.subject.keyword Newborn infant
dc.subject.keyword Cord blood
dc.subject.keyword Gene expression
dc.subject.keyword Innate immunity
dc.subject.keyword Immune adaptation
dc.identifier.urn URN:NBN:fi:aalto-201704283709
dc.identifier.doi 10.1016/j.clim.2014.09.009
dc.type.version publishedVersion

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