Investigating the Causal Role of rOFA in Holistic Detection of Mooney Faces and Objects

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Bona, Silvia
dc.contributor.author Cattaneo, Zaira
dc.contributor.author Silvanto, Juha
dc.date.accessioned 2017-04-28T09:43:29Z
dc.date.available 2017-04-28T09:43:29Z
dc.date.issued 2016-07-01
dc.identifier.citation Bona , S , Cattaneo , Z & Silvanto , J 2016 , ' Investigating the Causal Role of rOFA in Holistic Detection of Mooney Faces and Objects : An fMRI-guided TMS Study ' BRAIN STIMULATION , vol 9 , no. 4 , pp. 594-600 . DOI: 10.1016/j.brs.2016.04.003 en
dc.identifier.issn 1935-861X
dc.identifier.other PURE UUID: 03bde55f-8b9f-4c11-9fae-05cf6a7350d8
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/investigating-the-causal-role-of-rofa-in-holistic-detection-of-mooney-faces-and-objects(03bde55f-8b9f-4c11-9fae-05cf6a7350d8).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=84974808085&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/11746746/1_s2.0_S1935861X16300535_main.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/25290
dc.description.abstract Background The right occipital face area (rOFA) is known to be involved in face discrimination based on local featural information. Whether this region is also involved in global, holistic stimulus processing is not known. Objective We used fMRI-guided transcranial magnetic stimulation (TMS) to investigate whether rOFA is causally implicated in stimulus detection based on holistic processing, by the use of Mooney stimuli. Methods Two studies were carried out: In Experiment 1, participants performed a detection task involving Mooney faces and Mooney objects; Mooney stimuli lack distinguishable local features and can be detected solely via holistic processing (i.e. at a global level) with top-down guidance from previously stored representations. Experiment 2 required participants to detect shapes which are recognized via bottom-up integration of local (collinear) Gabor elements and was performed to control for specificity of rOFA's implication in holistic detection. Results In Experiment 1, TMS over rOFA and rLO impaired detection of all stimulus categories, with no category-specific effect. In Experiment 2, shape detection was impaired when TMS was applied over rLO but not over rOFA. Conclusions Our results demonstrate that rOFA is causally implicated in the type of top-down holistic detection required by Mooney stimuli and that such role is not face-selective. In contrast, rOFA does not appear to play a causal role in detection of shapes based on bottom-up integration of local components, demonstrating that its involvement in processing non-face stimuli is specific for holistic processing. en
dc.format.extent 7
dc.format.extent 594-600
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries BRAIN STIMULATION en
dc.relation.ispartofseries Volume 9, issue 4 en
dc.rights openAccess en
dc.subject.other Clinical Neurology en
dc.subject.other Neuroscience(all) en
dc.subject.other Biophysics en
dc.subject.other 3112 Neurosciences en
dc.title Investigating the Causal Role of rOFA in Holistic Detection of Mooney Faces and Objects en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Neuroscience and Biomedical Engineering
dc.contributor.department IRCCS Fondazione Istituto Neurologico Casimiro Mondino - Pavia
dc.contributor.department University of Westminster
dc.subject.keyword Face processing
dc.subject.keyword fMRI-guided TMS
dc.subject.keyword Holistic detection
dc.subject.keyword Object processing
dc.subject.keyword Occipital face area
dc.subject.keyword Visual cortex
dc.subject.keyword Clinical Neurology
dc.subject.keyword Neuroscience(all)
dc.subject.keyword Biophysics
dc.subject.keyword 3112 Neurosciences
dc.identifier.urn URN:NBN:fi:aalto-201704283693
dc.identifier.doi 10.1016/j.brs.2016.04.003
dc.type.version publishedVersion


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