Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Salmela, Elina
dc.contributor.author Renvall, Hanna
dc.contributor.author Kujala, Jan
dc.contributor.author Hakosalo, Osmo
dc.contributor.author Illman, Mia
dc.contributor.author Vihla, Minna
dc.contributor.author Leinonen, Eira
dc.contributor.author Salmelin, Riitta
dc.contributor.author Kere, Juha
dc.date.accessioned 2016-10-13T06:14:50Z
dc.date.issued 2016-07-04
dc.identifier.citation Salmela , E , Renvall , H , Kujala , J , Hakosalo , O , Illman , M , Vihla , M , Leinonen , E , Salmelin , R & Kere , J 2016 , ' Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity ' European Journal of Neuroscience , vol 44 , no. 3 , pp. 1963–1971 . DOI: 10.1111/ejn.13300 en
dc.identifier.issn 0953-816X
dc.identifier.issn 1460-9568
dc.identifier.other PURE UUID: b2ceea6a-aaea-4e1a-ae97-3b87b83a1f7b
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/evidence-for-genetic-regulation-of-the-human-parietooccipital-10hz-rhythmic-activity(b2ceea6a-aaea-4e1a-ae97-3b87b83a1f7b).html
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=84979059391&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/6946275/Salmela_et_al_2016_European_Journal_of_Neuroscience.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/22938
dc.description.abstract Several functional and morphological brain measures are partly under genetic control. The identification of direct links between neuroimaging signals and corresponding genetic factors can reveal cellular-level mechanisms behind the measured macroscopic signals and contribute to the use of imaging signals as probes of genetic function. To uncover possible genetic determinants of the most prominent brain signal oscillation, the parieto-occipital 10-Hz alpha rhythm, we measured spontaneous brain activity with magnetoencephalography in 210 healthy siblings while the subjects were resting, with eyes closed and open. The reactivity of the alpha rhythm was quantified from the difference spectra between the two conditions. We focused on three measures: peak frequency, peak amplitude and the width of the main spectral peak. In accordance with earlier electroencephalography studies, spectral peak amplitude was highly heritable (h2 > 0.75). Variance component-based analysis of 28 000 single-nucleotide polymorphism markers revealed linkage for both the width and the amplitude of the spectral peak. The strongest linkage was detected for the width of the spectral peak over the left parieto-occipital cortex on chromosome 10 (LOD = 2.814, nominal P <0.03). This genomic region contains several functionally plausible genes, including GRID1 and ATAD1 that regulate glutamate receptor channels mediating synaptic transmission, NRG3 with functions in brain development and HRT7 involved in the serotonergic system and circadian rhythm. Our data suggest that the alpha oscillation is in part genetically regulated, and that it may be possible to identify its regulators by genetic analyses on a realistically modest number of samples. en
dc.format.extent 9
dc.format.extent 1963–1971
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries European Journal of Neuroscience en
dc.relation.ispartofseries Volume 44, issue 3 en
dc.rights openAccess en
dc.subject.other Neuroscience(all) en
dc.subject.other 3112 Neurosciences en
dc.title Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Folkhälsan Institute of Genetics
dc.contributor.department Department of Neuroscience and Biomedical Engineering
dc.contributor.department University of Helsinki
dc.contributor.department City of Helsinki Health Centre
dc.contributor.department Karolinska Institutet
dc.subject.keyword Alpha rhythm
dc.subject.keyword Heritability
dc.subject.keyword Linkage study
dc.subject.keyword Magnetoencephalography
dc.subject.keyword Neuroscience(all)
dc.subject.keyword 3112 Neurosciences
dc.identifier.urn URN:NBN:fi:aalto-201610135038
dc.identifier.doi 10.1111/ejn.13300
dc.type.version publishedVersion


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