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Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Reux, Bastien
dc.contributor.author Nevalainen, Tapio
dc.contributor.author Raitio, Katri H.
dc.contributor.author Koskinen, Ari M.P.
dc.date.accessioned 2016-09-23T08:16:45Z
dc.date.issued 2009
dc.identifier.citation Reux , B , Nevalainen , T , Raitio , K H & Koskinen , A M P 2009 , ' Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 ' , BIOORGANIC AND MEDICINAL CHEMISTRY , vol. 17 , no. 13 , pp. 4441-4447 . https://doi.org/10.1016/j.bmc.2009.05.013 en
dc.identifier.issn 0968-0896
dc.identifier.other PURE UUID: 89154ef5-74e4-4337-877e-5d85d3db2d4d
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/89154ef5-74e4-4337-877e-5d85d3db2d4d
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/7159814/ms141.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/22322
dc.description.abstract A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor. en
dc.format.extent 4441-4447
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries BIOORGANIC AND MEDICINAL CHEMISTRY en
dc.relation.ispartofseries Volume 17, issue 13 en
dc.rights openAccess en
dc.title Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Chemistry en
dc.subject.keyword cannabinoid
dc.subject.keyword receptor CB2
dc.subject.keyword quinoline
dc.subject.keyword isoquinoline
dc.identifier.urn URN:NBN:fi:aalto-201609234326
dc.identifier.doi 10.1016/j.bmc.2009.05.013
dc.type.version acceptedVersion


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