Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

Reux, Bastien; Nevalainen, Tapio; Raitio, Katri H.; Koskinen, Ari M.P.

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dc.contributor	Aalto-yliopisto	fi
dc.contributor	Aalto University	en
dc.contributor.author	Reux, Bastien
dc.contributor.author	Nevalainen, Tapio
dc.contributor.author	Raitio, Katri H.
dc.contributor.author	Koskinen, Ari M.P.
dc.date.accessioned	2016-09-23T08:16:45Z
dc.date.issued	2009
dc.identifier.citation	Reux , B , Nevalainen , T , Raitio , K H & Koskinen , A M P 2009 , ' Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 ' , BIOORGANIC AND MEDICINAL CHEMISTRY , vol. 17 , no. 13 , pp. 4441-4447 . https://doi.org/10.1016/j.bmc.2009.05.013	en
dc.identifier.issn	0968-0896
dc.identifier.other	PURE UUID: 89154ef5-74e4-4337-877e-5d85d3db2d4d
dc.identifier.other	PURE ITEMURL: https://research.aalto.fi/en/publications/89154ef5-74e4-4337-877e-5d85d3db2d4d
dc.identifier.other	PURE FILEURL: https://research.aalto.fi/files/7159814/ms141.pdf
dc.identifier.uri	https://aaltodoc.aalto.fi/handle/123456789/22322
dc.description.abstract	A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.	en
dc.format.extent	4441-4447
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.relation.ispartofseries	BIOORGANIC AND MEDICINAL CHEMISTRY	en
dc.relation.ispartofseries	Volume 17, issue 13	en
dc.rights	openAccess	en
dc.title	Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2	en
dc.type	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä	fi
dc.description.version	Peer reviewed	en
dc.contributor.department	Department of Chemistry	en
dc.subject.keyword	cannabinoid
dc.subject.keyword	receptor CB2
dc.subject.keyword	quinoline
dc.subject.keyword	isoquinoline
dc.identifier.urn	URN:NBN:fi:aalto-201609234326
dc.identifier.doi	10.1016/j.bmc.2009.05.013
dc.type.version	acceptedVersion