Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Fagerholm, Annika E.
dc.contributor.author Habrant, Damien
dc.contributor.author Koskinen, Ari M.P.
dc.date.accessioned 2016-09-09T06:55:42Z
dc.date.issued 2010
dc.identifier.citation Fagerholm , A E , Habrant , D & Koskinen , A M P 2010 , ' Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C ' MARINE DRUGS , vol 8 , no. 1 , pp. 122-172 . en
dc.identifier.other PURE UUID: 976fcfa2-9196-4cab-abf9-c78a8fd0f4ab
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/calyculins-and-related-marine-natural-products-as-serinethreonine-protein-phosphatase-pp1-and-pp2a-inhibitors-and-total-syntheses-of-calyculin-a-b-and-c(976fcfa2-9196-4cab-abf9-c78a8fd0f4ab).html
dc.identifier.other PURE LINK: http://dx.doi.org/10.3390/md80100122
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/6998664/Calyculins_and_Related_Marine_Natural_Products.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/21901
dc.description.abstract Calyculins, highly cytotoxic polyketides, originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers, belong to the lithistid sponges group. These molecules have become interesting targets for cell biologists and synthetic organic chemists. The serine/threonine protein phosphatases play an essential role in the cellular signalling, metabolism, and cell cycle control. Calyculins express potent protein phosphatase 1 and 2A inhibitory activity, and have therefore become valuable tools for cellular biologists studying intracellular processes and their control by reversible phosphorylation. Calyculins might also play an important role in the development of several diseases such as cancer, neurodegenerative diseases, and type 2-diabetes mellitus. The fascinating structures of calyculins have inspired various groups of synthetic organic chemists to develop total syntheses of the most abundant calyculins A and C. However, with fifteen chiral centres, a cyano-capped tetraene unit, a phosphate-bearing spiroketal, an anti, anti, anti dipropionate segment, an α-chiral oxazole, and a trihydroxylated γ-amino acid, calyculins reach versatility that only few natural products can surpass, and truly challenge modern chemists’ asymmetric synthesis skills. en
dc.format.extent 122-172
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries MARINE DRUGS en
dc.relation.ispartofseries Volume 8, issue 1 en
dc.rights openAccess en
dc.subject.other 116 Chemical sciences en
dc.title Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Chemistry en
dc.subject.keyword Total Syntheses, Calyculin, Marine Natural Products
dc.subject.keyword Total Synthesis
dc.subject.keyword marine natural products
dc.subject.keyword protein phosphatase inhibitors
dc.subject.keyword 116 Chemical sciences
dc.identifier.urn URN:NBN:fi:aalto-201609093790
dc.type.version publishedVersion


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