Human ROBO1 Regulates Interaural Interaction in Auditory Pathways

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Lamminmaki, S.
dc.contributor.author Massinen, S.
dc.contributor.author Nopola-Hemmi, J.
dc.contributor.author Kere, J.
dc.contributor.author Hari, Riitta
dc.date.accessioned 2015-11-23T10:02:19Z
dc.date.available 2015-11-23T10:02:19Z
dc.date.issued 2012
dc.identifier.citation Lamminmaki, S. & Massinen, S. & Nopola-Hemmi, J. & Kere, J. & Hari, Riitta. 2012. Human ROBO1 Regulates Interaural Interaction in Auditory Pathways. Journal of Neuroscience. Volume 32, Issue 3. 966-971. ISSN 0270-6474 (printed). DOI: 10.1523/jneurosci.4007-11.2012. en
dc.identifier.issn 0270-6474 (printed)
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/18714
dc.description.abstract In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level. en
dc.format.extent 966-971
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Society for Neuroscience en
dc.relation.ispartofseries Journal of Neuroscience en
dc.relation.ispartofseries Volume 32, Issue 3
dc.rights © 2012 Society for Neuroscience. This is the accepted version of the following article: Lamminmaki, S. & Massinen, S. & Nopola-Hemmi, J. & Kere, J. & Hari, Riitta. 2012. Human ROBO1 Regulates Interaural Interaction in Auditory Pathways. Journal of Neuroscience. Volume 32, Issue 3. 966-971. ISSN 0270-6474 (printed). DOI: 10.1523/jneurosci.4007-11.2012, which has been published in final form at http://www.jneurosci.org/content/32/3/966.full. en
dc.subject.other Medical sciences en
dc.title Human ROBO1 Regulates Interaural Interaction in Auditory Pathways en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.rights.holder Society for Neuroscience
dc.contributor.school Perustieteiden korkeakoulu fi
dc.contributor.school School of Science en
dc.contributor.department Neurotieteen ja lääketieteellisen tekniikan laitos fi
dc.contributor.department Department of Neuroscience and Biomedical Engineering en
dc.subject.keyword Robo1 gene en
dc.subject.keyword magnetoencephalography en
dc.subject.keyword dyslexia en
dc.identifier.urn URN:NBN:fi:aalto-201511185078
dc.type.dcmitype text en
dc.identifier.doi 10.1523/jneurosci.4007-11.2012
dc.type.version Final published version en


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