Production of L-Leucine Nanoparticles under Various Conditions Using an Aerosol Flow Reactor Method

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en Lähde, Anna Raula, Janne Kauppinen, Esko I. 2015-10-30T10:02:14Z 2015-10-30T10:02:14Z 2008
dc.identifier.citation Lähde, Anna & Raula, Janne & Kauppinen, Esko I. 2008. Production of L-Leucine Nanoparticles under Various Conditions Using an Aerosol Flow Reactor Method. Journal of Nanomaterials. Volume 2008. 680897/1-9. ISSN 1687-4110 (printed). DOI: 10.1155/2008/680897 en
dc.identifier.issn 1687-4110 (printed)
dc.description.abstract We have studied the formation of L-leucine nanoparticles under various conditions using an aerosol flow reactor method. Temperatures and L-leucine concentrations for the experiments were selected to vary the saturation conditions for L-leucine in the reactor. In the two extreme cases, L-leucine is either in (i) the condensed phase (110 ∘C) or completely in (ii) the vapour phase (200 ∘C) for all concentrations; (iii) at the intermediate temperature (150 ∘C), the extent of evaporation of L-leucine depends notably on the concentration, and thus partial evaporation and production of residual particles are expected. The size distribution of particles and the particle morphology varied according to formation mechanism with the geometric mean diameter of the particles between 30 nm and 210 nm. Hollow, spherical particles were obtained with the droplet-to-particle method without vaporisation of L-leucine; whereas leafy-looking particles were produced by homogeneous nucleation of supersaturated L-leucine vapour and subsequent growth by heterogeneous vapour deposition. en
dc.format.extent 680897/1-9
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Hindawi Publishing Corporation en
dc.relation.ispartofseries Journal of Nanomaterials en
dc.relation.ispartofseries Volume 2008
dc.rights © 2008 Authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.subject.other Physics en
dc.title Production of L-Leucine Nanoparticles under Various Conditions Using an Aerosol Flow Reactor Method en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.rights.holder Authors Perustieteiden korkeakoulu fi School of Science en
dc.contributor.department Teknillisen fysiikan laitos fi
dc.contributor.department Department of Applied Physics en
dc.subject.keyword L-leucine nanoparticles en
dc.subject.keyword formation en
dc.subject.keyword aerosol flow reactor method en
dc.subject.keyword pharmaceutical particles en
dc.subject.keyword gas phase en
dc.identifier.urn URN:NBN:fi:aalto-201510304807
dc.type.dcmitype text en
dc.identifier.doi 10.1155/2008/680897
dc.type.version Final published version en

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