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Genome-Wide Linkage Analysis of Human Auditory Cortical Activation Suggests Distinct Loci on Chromosomes 2, 3, and 8

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Renvall, H.
dc.contributor.author Salmela, E.
dc.contributor.author Vihla, M.
dc.contributor.author Illman, M.
dc.contributor.author Leinonen, E.
dc.contributor.author Kere, J.
dc.contributor.author Salmelin, Riitta
dc.date.accessioned 2015-05-19T09:00:43Z
dc.date.available 2015-05-19T09:00:43Z
dc.date.issued 2012
dc.identifier.citation Renvall, H. & Salmela, E. & Vihla, M. & Illman, M. & Leinonen, E. & Kere, J. & Salmelin, Riitta. 2012. Genome-Wide Linkage Analysis of Human Auditory Cortical Activation Suggests Distinct Loci on Chromosomes 2, 3, and 8. Journal of Neuroscience. Volume 32, Issue 42. P. 14511-14518. ISSN 0270-6474 (printed). DOI: 10.1523/jneurosci.1483-12.2012. en
dc.identifier.issn 0270-6474 (printed)
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/16075
dc.description.abstract Neural processes are explored through macroscopic neuroimaging and microscopic molecular measures, but the two levels remain primarily detached. The identification of direct links between the levels would facilitate use of imaging signals as probes of genetic function and, vice versa, access to molecular correlates of imaging measures. Neuroimaging patterns have been mapped for a few isolated genes, chosen based on their connection with a clinical disorder. Here we propose an approach that allows an unrestricted discovery of the genetic basis of a neuroimaging phenotype in the normal human brain. The essential components are a subject population that is composed of relatives and selection of a neuroimaging phenotype that is reproducible within an individual and similar between relatives but markedly variable across a population. Our present combined magnetoencephalography and genome-wide linkage study in 212 healthy siblings demonstrates that auditory cortical activation strength is highly heritable and, specifically in the right hemisphere, regulated oligogenically with linkages to chromosomes 2q37, 3p12, and 8q24. The identified regions delimit as candidate genes TRAPPC9, operating in neuronal differentiation, and ROBO1, regulating projections of thalamocortical axons. Identification of normal genetic variation underlying neurophysiological phenotypes offers a non-invasive platform for an in-depth, concerted capitalization of molecular and neuroimaging levels in exploring neural function. en
dc.format.extent 14511-14518
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Society for Neuroscience en
dc.relation.ispartofseries Journal of Neuroscience en
dc.relation.ispartofseries Volume 32, Issue 42
dc.rights © 2012 Authors. This article has been published in The Journal of Neuroscience under a Creative Commons Attribution 4.0 International (CC BY 4.0) license en
dc.subject.other Medical sciences en
dc.title Genome-Wide Linkage Analysis of Human Auditory Cortical Activation Suggests Distinct Loci on Chromosomes 2, 3, and 8 en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.rights.holder Authors
dc.contributor.school Perustieteiden korkeakoulu fi
dc.contributor.school School of Science en
dc.contributor.department Neurotieteen ja lääketieteellisen tekniikan laitos fi
dc.contributor.department Department of Neuroscience and Biomedical Engineering en
dc.subject.keyword neural processes en
dc.subject.keyword macroscopic neuroimaging en
dc.subject.keyword microscopic molecular measures en
dc.identifier.urn URN:NBN:fi:aalto-201505182716
dc.type.dcmitype text en
dc.identifier.doi 10.1523/jneurosci.1483-12.2012
dc.type.version Final published version en

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