Abnormal Auditory Cortical Activation in Dyslexia 100 msec after Speech Onset

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Helenius, Päivi
dc.contributor.author Salmelin, Riitta
dc.contributor.author Richardson, Ulla
dc.contributor.author Leinonen, Seija
dc.contributor.author Lyytinen, Heikki
dc.date.accessioned 2015-05-18T09:00:56Z
dc.date.available 2015-05-18T09:00:56Z
dc.date.issued 2002
dc.identifier.citation Helenius, Päivi & Salmelin, Riitta & Richardson, Ulla & Leinonen, Seija & Lyytinen, Heikki. 2002. Abnormal Auditory Cortical Activation in Dyslexia 100 msec after Speech Onset. Journal of Cognitive Neuroscience. Volume 14, Issue 4. P. 603-617. ISSN 0898-929X (printed). DOI: 10.1162/08989290260045846. en
dc.identifier.issn 0898-929X (printed)
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/16068
dc.description.abstract Reading difficulties are associated with problems in processing and manipulating speech sounds. Dyslexic individuals seem to have, for instance, difficulties in perceiving the length and identity of consonants. Using magnetoencephalography (MEG), we characterized the spatio-temporal pattern of auditory cortical activation in dyslexia evoked by three types of natural bisyllabic pseudowords (/ata/, /atta/, and /a a/), complex nonspeech sound pairs (corresponding to /atta/ and /a a/) and simple 1-kHz tones. The most robust difference between dyslexic and non-reading-impaired adults was seen in the left supratemporal auditory cortex 100 msec after the onset of the vowel /a/. This N100m response was abnormally strong in dyslexic individuals. For the complex nonspeech sounds and tone, the N100m response amplitudes were similar in dyslexic and nonimpaired individuals. The responses evoked by syllable /ta/ of the pseudoword /atta/ also showed modest latency differences between the two subject groups. The responses evoked by the corresponding nonspeech sounds did not differ between the two subject groups. Further, when the initial formant transition, that is, the consonant, was removed from the syllable /ta/, the N100m latency was normal in dyslexic individuals. Thus, it appears that dyslexia is reflected as abnormal activation of the auditory cortex already 100 msec after speech onset, manifested as abnormal response strengths for natural speech and as delays for speech sounds containing rapid frequency transition. These differences between the dyslexic and nonimpaired individuals also imply that the N100m response codes stimulus-specific features likely to be critical for speech perception. Which features of speech (or nonspeech stimuli) are critical in eliciting the abnormally strong N100m response in dyslexic individuals should be resolved in future studies. en
dc.format.extent 603-617
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MIT Press en
dc.relation.ispartofseries Journal of Cognitive Neuroscience en
dc.relation.ispartofseries Volume 14, Issue 4
dc.rights © 2002 MIT Press. This is the final version of the article: Helenius, Päivi ; Salmelin, Riitta ; Richardson, Ulla ; Leinonen, Seija ; Lyytinen, Heikki. 2002. Abnormal Auditory Cortical Activation in Dyslexia 100 msec after Speech Onset. Journal of Cognitive Neuroscience. Volume 14, Issue 4. P. 603-617. ISSN 0898-929X (printed). DOI: 10.1162/08989290260045846, which has been published in final form at http://www.mitpressjournals.org/doi/abs/10.1162/08989290260045846#.VVmkumOkuSo en
dc.subject.other Linguistics en
dc.subject.other Medical sciences en
dc.title Abnormal Auditory Cortical Activation in Dyslexia 100 msec after Speech Onset en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.rights.holder MIT Press
dc.contributor.school Perustieteiden korkeakoulu fi
dc.contributor.school School of Science en
dc.contributor.department Neurotieteen ja lääketieteellisen tekniikan laitos fi
dc.contributor.department Department of Neuroscience and Biomedical Engineering en
dc.subject.keyword auditory cortical activation en
dc.subject.keyword dyslexia en
dc.subject.keyword speech onset en
dc.identifier.urn URN:NBN:fi:aalto-201505182711
dc.type.dcmitype text en
dc.identifier.doi 10.1162/08989290260045846
dc.type.version Final published version en


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