Sequence Dependence of DNA Translocation through a Nanopore

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Luo, Kaifu
dc.contributor.author Ala-Nissilä, Tapio
dc.contributor.author Ying, See-Chen
dc.contributor.author Bhattacharya, Aniket
dc.date.accessioned 2015-04-29T09:01:16Z
dc.date.available 2015-04-29T09:01:16Z
dc.date.issued 2008
dc.identifier.citation Luo, Kaifu & Ala-Nissilä, Tapio & Ying, See-Chen & Bhattacharya, Aniket. 2008. Sequence Dependence of DNA Translocation through a Nanopore. Physical Review Letters. Volume 100, Issue 5. P. 058101/1-4. ISSN 0031-9007 (printed). DOI: 10.1103/physrevlett.100.058101. en
dc.identifier.issn 0031-9007 (printed)
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/15838
dc.description.abstract We investigate the dynamics of DNA translocation through a nanopore using 2D Langevin dynamics simulations, focusing on the dependence of the translocation dynamics on the details of DNA sequences. The DNA molecules studied in this work are built from two types of bases A and C, which have been shown previously to have different interactions with the pore. We study DNA with repeating blocks AnCn for various values of n and find that the translocation time depends strongly on the block length 2n as well as on the orientation of which base enters the pore first. Thus, we demonstrate that the measurement of translocation dynamics of DNA through a nanopore can yield detailed information about its structure. We have also found that the periodicity of the block sequences is contained in the periodicity of the residence time of the individual nucleotides inside the pore. en
dc.format.extent 058101/1-4
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Physical Society (APS) en
dc.relation.ispartofseries Physical Review Letters en
dc.relation.ispartofseries Volume 100, Issue 5
dc.rights © 2008 American Physical Society (APS). http://www.aps.org/ en
dc.subject.other Physics en
dc.title Sequence Dependence of DNA Translocation through a Nanopore en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.rights.holder American Physical Society (APS)
dc.contributor.school Perustieteiden korkeakoulu fi
dc.contributor.school School of Science en
dc.contributor.department Teknillisen fysiikan laitos fi
dc.contributor.department Department of Applied Physics en
dc.subject.keyword polymers en
dc.subject.keyword translocation en
dc.subject.keyword nanopore en
dc.identifier.urn URN:NBN:fi:aalto-201504292498
dc.type.dcmitype text en
dc.identifier.doi 10.1103/physrevlett.100.058101
dc.type.version Final published version en


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