Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults : Symptomatic COVID-19 only contracted by those without recent infection

Riekkinen, Marianna; Kajova, Mikael; Eriksson, Mari; Luukkainen, Annika; Holmberg, Ville; Aro, Tuomas; Pakkanen, Sari H.; Miettinen, Simo; Montonen, Reetta; Smura, Teemu; Lääveri, Tinja; Kantele, Anu

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Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults : Symptomatic COVID-19 only contracted by those without recent infection

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Title:	Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults : Symptomatic COVID-19 only contracted by those without recent infection
Author(s):	Riekkinen, Marianna ; Kajova, Mikael ; Eriksson, Mari ; Luukkainen, Annika ; Holmberg, Ville ; Aro, Tuomas ; Pakkanen, Sari H. ; Miettinen, Simo ; Montonen, Reetta ; Smura, Teemu ; Lääveri, Tinja ; Kantele, Anu
Date:	2023-07-04
Language:	en
Department:	University of Helsinki Professorship Viitanen Johanna Department of Computer Science
Series:	Epidemiology and Infection, Volume 151
ISSN:	0950-2688 1469-4409
DOI-number:	10.1017/S0950268823001024
Keywords:	COVID-19, Hybrid immunity, Omicron, SARS-CoV-2, Superspreading event
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Citation: Riekkinen , M , Kajova , M , Eriksson , M , Luukkainen , A , Holmberg , V , Aro , T , Pakkanen , S H , Miettinen , S , Montonen , R , Smura , T , Lääveri , T & Kantele , A 2023 , ' Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults : Symptomatic COVID-19 only contracted by those without recent infection ' , Epidemiology and Infection , vol. 151 , e113 . https://doi.org/10.1017/S0950268823001024
Abstract: An outbreak of SARS-CoV-2 was confirmed after an academic party in Helsinki, Finland, in 2022. All 70 guests were requested to fill in follow-up questionnaires; serologic analyses and whole-genome sequencing (WGS) were conducted when possible. Of those participating - all but one with ≥3 vaccine doses - 21/53 (40%) had testconfirmed symptomatic COVID-19: 7% of those with earlier episodes and 76% of those without. Half (11/21) were febrile, but none needed hospitalization. WGS revealed subvariant BA.2.23. Compared to vaccination alone, our data suggest remarkable protection by hybrid immunity against symptomatic infection, particularly in instances of recent infections with homologous variants.

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