LAVAA: A lightweight association viewer across ailments

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Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2023
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Language
en
Pages
7
Series
Bioinformatics Advances
Abstract
Motivation: Biobank scale genetic associations results over thousands of traits can be difficult to visualize and navigate. Results: We have created LAVAA, a visualization web-application to generate genetic volcano plots for simultaneously considering the P-value, effect size, case counts, trait class and fine-mapping posterior probability at a singlenucleotide polymorphism (SNP) across a range of traits from a large set of genome-wide association study. We find that user interaction with association results in LAVAA can enrich and enhance the biological interpretation of individual loci. Availability and implementation: LAVAA is available as a stand-alone web service (https://geneviz.aalto.fi/LAVAA/) and will be available in future releases of the finngen.fi website starting with release 10 in late 2023.
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Citation
Fauman , E B , Keppo , S , Cerioli , N , Vyas , R , Kurki , M , Daly , M J & Reeve , M P 2023 , ' LAVAA: A lightweight association viewer across ailments ' , Bioinformatics Advances , vol. 3 , no. 1 , vbad018 . https://doi.org/10.1093/bioadv/vbad018