PLA2 Interfacial Activation on Lipid Interfaces Promoting Fibril Formation

Code, Christian

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dc.contributor	Aalto-yliopisto	fi
dc.contributor	Aalto University	en
dc.contributor.advisor	Kinnunen, Paavo K. J., Prof., Aalto University, Department of Biomedical Engineering and Computational Science, Finland
dc.contributor.author	Code, Christian
dc.date.accessioned	2013-11-13T10:00:43Z
dc.date.available	2013-11-13T10:00:43Z
dc.date.issued	2013
dc.identifier.isbn	978-952-60-5382-0 (electronic)
dc.identifier.isbn	978-952-60-5381-3 (printed)
dc.identifier.issn	1799-4942 (electronic)
dc.identifier.issn	1799-4934 (printed)
dc.identifier.issn	1799-4934 (ISSN-L)
dc.identifier.uri	https://aaltodoc.aalto.fi/handle/123456789/11342
dc.description.abstract	Phospholipase A2 is a widely studied protein found ubiquitously in nature. The protein interacts with the lipid membrane cleaving the phospholipid at the sn-2 position. The interfacial activation mechanism is characterized by a low activity on monomeric substrates but a greatly enhanced activity on aggregated substrates. Several of our papers have elucidated the complex interfacial activation mechanism of this protein from different angles in two very diverse scientific frames: from the view of the lipid and the view of the protein. In this thesis the interfacial activation mechanism of PLA2 is understood to behave in a temporal sequence of events first by binding, dimer formation, oligomer formation and finally by the formation of amyloid-like fibrils.	en
dc.format.extent	66 + app. 44
dc.format.mimetype	application/pdf
dc.language.iso	en	en
dc.publisher	Aalto University	en
dc.publisher	Aalto-yliopisto	fi
dc.relation.ispartofseries	Aalto University publication series DOCTORAL DISSERTATIONS	en
dc.relation.ispartofseries	164/2013
dc.relation.haspart	[Publication 1]: Code C, Domanov Y, Jutila A, Kinnunen PK. Amyloid-type fiber formation in control of enzyme action: interfacial activation of phospholipase A2. Biophys J. 2008 Jul;95(1):215-24.
dc.relation.haspart	[Publication 2]: Code C, Domanov YA, Killian JA, Kinnunen PK. Activation of phospholipase A(2) by temporin B: Formation of antimicrobial peptide-enzyme amyloid-type cofibrils. Biochim Biophys Acta. 2009 May;1788(5):1064-72.
dc.relation.haspart	[Publication 3]: Code C, Mahalka AK, Bry K, Kinnunen PK. Activation of phospholipase A2 by 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine in vitro. Biochim Biophys Acta. 2010 Aug;1798(8):1593-600.
dc.relation.haspart	[Publication 4]: Mahalka AK, Code C, Rezaijahromi B, Kirkegaard T, Jäättelä M, Kinnunen PK. Activation of phospholipase A2 by HSP70 in vitro. Biochim Biophys Acta. 2011 Oct;1808 (10): 2569–72.
dc.subject.other	Biotechnology	en
dc.title	PLA2 Interfacial Activation on Lipid Interfaces Promoting Fibril Formation	en
dc.type	G5 Artikkeliväitöskirja	fi
dc.contributor.school	Perustieteiden korkeakoulu	fi
dc.contributor.school	School of Science	en
dc.contributor.department	Lääketieteellisen tekniikan ja laskennallisen tieteen laitos	fi
dc.contributor.department	Department of Biomedical Engineering and Computational Science	en
dc.subject.keyword	liposome	en
dc.subject.keyword	PLA2	en
dc.subject.keyword	peptide	en
dc.subject.keyword	phospholipid	en
dc.subject.keyword	amyloid	en
dc.subject.keyword	protein-lipid interaction	en
dc.subject.keyword	dimer	en
dc.subject.keyword	temporin B	en
dc.subject.keyword	heat-shock protein	en
dc.subject.keyword	oxidized phospholipids	en
dc.identifier.urn	URN:ISBN:978-952-60-5382-0
dc.type.dcmitype	text	en
dc.type.ontasot	Doctoral dissertation (article-based)	en
dc.type.ontasot	Väitöskirja (artikkeli)	fi
dc.contributor.supervisor	Kinnunen, Paavo K. J., Prof., Aalto University, Department of Biomedical Engineering and Computational Science, Finland
dc.opn	Sammalkorpi, Maria, D.Sc. Aalto University, Department of Chemistry, Finland
dc.contributor.lab	Helsinki Biophysics and Biomembrane Group	en
dc.rev	Olkkonen, Vesa, Prof., Minerva Institute for Medical Research, Finland; Mattjus, Peter, Ph.D., Docent, Åbo Akademi University, Finland
dc.date.defence	2013-11-01
local.aalto.digifolder	Aalto_64348
local.aalto.digiauth	ask

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