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Picture naming yields highly consistent cortical activation patterns

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Ala-Salomäki, Heidi
dc.contributor.author Kujala, Jan
dc.contributor.author Liljeström, Mia
dc.contributor.author Salmelin, Riitta
dc.date.accessioned 2021-01-25T10:14:33Z
dc.date.available 2021-01-25T10:14:33Z
dc.date.issued 2021-02-15
dc.identifier.citation Ala-Salomäki , H , Kujala , J , Liljeström , M & Salmelin , R 2021 , ' Picture naming yields highly consistent cortical activation patterns : Test–retest reliability of magnetoencephalography recordings ' , NeuroImage , vol. 227 , 117651 . https://doi.org/10.1016/j.neuroimage.2020.117651 en
dc.identifier.issn 1053-8119
dc.identifier.issn 1095-9572
dc.identifier.other PURE UUID: 851e2e29-a559-4836-bb04-ede8aa6d1457
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/851e2e29-a559-4836-bb04-ede8aa6d1457
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85098127610&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/54903204/Ala_Salom_ki_Picture_Naming.1_s2.0_S1053811920311368_main.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/102199
dc.description.abstract Reliable paradigms and imaging measures of individual-level brain activity are paramount when reaching from group-level research studies to clinical assessment of individual patients. Magnetoencephalography (MEG) provides a direct, non-invasive measure of cortical processing with high spatiotemporal accuracy, and is thus well suited for assessment of functional brain damage in patients with language difficulties. This MEG study aimed to identify, in a delayed picture naming paradigm, source-localized evoked activity and modulations of cortical oscillations that show high test–retest reliability across measurement days in healthy individuals, demonstrating their applicability in clinical settings. For patients with a language disorder picture naming can be a challenging task. Therefore, we also determined whether a semantic judgment task (‘Is this item living?’) with a spoken response (“yes”/“no”) would suffice to induce comparably consistent activity within brain regions related to language production. The MEG data was collected from 19 healthy participants on two separate days. In picture naming, evoked activity was consistent across measurement days (intraclass correlation coefficient (ICC)>0.4) in the left frontal (400–800 ms after image onset), sensorimotor (200–800 ms), parietal (200–600 ms), temporal (200–800 ms), occipital (400–800 ms) and cingulate (600–800 ms) regions, as well as the right temporal (600–800 ms) region. In the semantic judgment task, consistent evoked activity was spatially more limited, occurring in the left temporal (200–800 ms), sensorimotor (400–800 ms), occipital (400–600 ms) and subparietal (600–800 ms) regions, and the right supramarginal cortex (600–800 ms). The delayed naming task showed typical beta oscillatory suppression in premotor and sensorimotor regions (800–1200 ms) but other consistent modulations of oscillatory activity were mostly observed in posterior cortical regions that have not typically been associated with language processing. The high test–retest consistency ofMEG evoked activity in the picture naming task testifies to its applicability in clinical evaluations of language function, as well as in longitudinal MEG studies of language production in clinical and healthy populations. en
dc.format.extent 12
dc.format.mimetype application/pdf
dc.language.iso en en
dc.relation.ispartofseries NeuroImage en
dc.relation.ispartofseries Volume 227 en
dc.rights openAccess en
dc.title Picture naming yields highly consistent cortical activation patterns en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Department of Neuroscience and Biomedical Engineering
dc.subject.keyword Individual assessment
dc.subject.keyword MEG
dc.subject.keyword Picture naming
dc.subject.keyword Reproducibility
dc.subject.keyword Semantic judgment
dc.subject.keyword Test–retest
dc.identifier.urn URN:NBN:fi:aalto-202101251509
dc.identifier.doi 10.1016/j.neuroimage.2020.117651
dc.type.version publishedVersion

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