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Modeling and optimization of polyethylene glycol (PEG) addition for cost-efficient enzymatic hydrolysis of lignocellulose

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dc.contributor Aalto-yliopisto fi
dc.contributor Aalto University en
dc.contributor.author Pihlajaniemi, Ville
dc.contributor.author Kallioinen, Anne
dc.contributor.author Sipponen, Mika
dc.contributor.author Nyyssölä, Antti
dc.date.accessioned 2021-01-25T10:08:57Z
dc.date.available 2021-01-25T10:08:57Z
dc.date.issued 2021-03
dc.identifier.citation Pihlajaniemi , V , Kallioinen , A , Sipponen , M & Nyyssölä , A 2021 , ' Modeling and optimization of polyethylene glycol (PEG) addition for cost-efficient enzymatic hydrolysis of lignocellulose ' , BIOCHEMICAL ENGINEERING JOURNAL , vol. 167 , 107894 . https://doi.org/10.1016/j.bej.2020.107894 en
dc.identifier.issn 1369-703X
dc.identifier.other PURE UUID: 23b48a9d-eada-4ee0-9031-c66fc9fc0389
dc.identifier.other PURE ITEMURL: https://research.aalto.fi/en/publications/23b48a9d-eada-4ee0-9031-c66fc9fc0389
dc.identifier.other PURE LINK: http://www.scopus.com/inward/record.url?scp=85099118935&partnerID=8YFLogxK
dc.identifier.other PURE FILEURL: https://research.aalto.fi/files/54774346/CHEM_Pihlajaniemi_et_al_Modeling_and_optimization_of_polyethylene_glycol_Biochemical_Engineering_Journal.pdf
dc.identifier.uri https://aaltodoc.aalto.fi/handle/123456789/102098
dc.description.abstract Enzyme consumption is a key cost in the lignocellulosic sugar route for production of biofuels and chemicals, and polyethylene glycol (PEG) is a low-cost additive that improves hydrolysis efficiency. Despite many studies in this area, the relation of benefit over cost of PEG addition remains unclear. This article describes principles for expressing the effect of PEG as an equivalent enzyme amount, by merging PEG adsorption kinetics with a standardized enzyme dosage response. This model allows cost optimization of PEG addition by marginal analysis, as a function of enzyme dosage, solids concentration and price-ratio of enzyme and PEG. The model is based on the novel observations that the relative increase in apparent enzyme dosage by PEG addition is constant regardless of the absolute enzyme dosage, and that the increase correlates linearly with adsorption of PEG on hydrothermally pretreated wheat straw. The optimum ranged for most cases between 7 and 14 mg PEG per g substrate. The addition of PEG was attractive only above a threshold price-ratio, which decreased from 7.0–1.4 as enzyme dosage increased from 2 to 10 cost units per g substrate, showing that the incentive for introducing PEG to the process becomes stronger as the enzyme dosage increases. en
dc.format.extent 8
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Elsevier
dc.relation.ispartofseries BIOCHEMICAL ENGINEERING JOURNAL en
dc.relation.ispartofseries Volume 167 en
dc.rights openAccess en
dc.title Modeling and optimization of polyethylene glycol (PEG) addition for cost-efficient enzymatic hydrolysis of lignocellulose en
dc.type A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä fi
dc.description.version Peer reviewed en
dc.contributor.department Bioproduct Chemistry
dc.contributor.department Department of Bioproducts and Biosystems en
dc.subject.keyword wheat straw
dc.subject.keyword cellulase
dc.subject.keyword hydrolysis additive
dc.subject.keyword Langmuir
dc.subject.keyword nonproductive binding
dc.subject.keyword marginal benefit
dc.identifier.urn URN:NBN:fi:aalto-202101251407
dc.identifier.doi 10.1016/j.bej.2020.107894
dc.date.embargo info:eu-repo/date/embargoEnd/2022-12-26

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