Browsing by Department "University of Tasmania"

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Discovery of Periodinane Oxy-Assisted (POA) Oxidation Mechanism in the IBX-Controlled Oxidative Dearomatization of Pyrroles Mediated by Acetic Acid
(2022-10-07) Farshadfar, Kaveh; Gunawan, Nina; Shiri, Farshad; Howard, James K.; Vaas, Andaravaas Patabadige Jude P.; Bissember, Alex C.; Yates, Brian F.; Smith, Jason A.; Ariafard, Alireza
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The 2-iodoxybenzoic acid (IBX)-controlled oxidative dearomatization of pyrroles occurs very slowly (or not all) in many organic solvents, including DMSO in which IBX is soluble. Interestingly, although IBX is only partially soluble in acetic acid, this solvent mediates the pyrrole oxidative dearomatization. With the aid of density functional theory (DFT) calculations, we have discovered a new mode of reactivity, termed the periodinane oxy-assisted (POA) oxidation mechanism, which explains this observation.
Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
(2022-03-01) Jha, Niraj Kumar; Chen, Wei Chih; Kumar, Sanjay; Dubey, Rajni; Tsai, Lung Wen; Kar, Rohan; Jha, Saurabh Kumar; Gupta, Piyush Kumar; Sharma, Ankur; Gundamaraju, Rohit; Pant, Kumud; Mani, Shalini; Singh, Sandeep Kumar; Maccioni, Ricardo B.; Datta, Tirtharaj; Singh, Sachin Kumar; Gupta, Gaurav; Prasher, Parteek; Dua, Kamal; Dey, Abhijit; Sharma, Charu; Mughal, Yasir Hayat; Ruokolainen, Janne; Kesari, Kavindra Kumar; Ojha, Shreesh
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term 'embryonic' might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic development and adulthood, albeit to a certain degree. Therefore, any aberration in these pathways or their associated components may contribute towards a detrimental outcome in the form of neurological disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. In the last decade, researchers have extensively studied these pathways to decipher disease-related interactions, which can be used as therapeutic targets to improve outcomes in patients with neurological abnormalities. However, a lot remains to be understood in this domain. Nevertheless, there is strong evidence supporting the fact that embryonic signalling is indeed a crucial mechanism as is manifested by its role in driving memory loss, motor impairments and many other processes after brain trauma. In this review, we explore the key roles of three embryonic pathways in modulating a range of homeostatic processes such as maintaining blood-brain barrier integrity, mitochondrial dynamics and neuroinflammation. In addition, we extensively investigated the effect of these pathways in driving the pathophysiology of a range of disorders such as Alzheimer's, Parkinson's and diabetic neuropathy. The concluding section of the review is dedicated to neurotherapeutics, wherein we identify and list a range of biological molecules and compounds that have shown enormous potential in improving prognosis in patients with these disorders.
Planetary Radio Interferometry and Doppler Experiment (PRIDE) technique
(2016-09-01) Duev, D. A.; Pogrebenko, S. V.; Cimò, G.; Molera Calvés, G.; Bocanegra Bahamón, T. M.; Gurvits, L. I.; Kettenis, M. M.; Kania, J.; Tudose, V.; Rosenblatt, P.; Marty, J. C.; Lainey, V.; De Vicente, P.; Quick, J.; Nickola, M.; Neidhardt, A.; Kronschnabl, G.; Ploetz, C.; Haas, R.; Lindqvist, Michael; Orlati, A.; Ipatov, A. V.; Kharinov, M. A.; Mikhailov, A. G.; Lovell, J. E J; McCallum, J. N.; Stevens, J.; Gulyaev, S. A.; Natush, T.; Weston, S.; Wang, W. H.; Xia, B.; Yang, W. J.; Hao, L. F.; Kallunki, J.; Witasse, O.
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Context. The closest ever fly-by of the Martian moon Phobos, performed by the European Space Agency's Mars Express spacecraft, gives a unique opportunity to sharpen and test the Planetary Radio Interferometry and Doppler Experiments (PRIDE) technique in the interest of studying planet-satellite systems. Aims. The aim of this work is to demonstrate a technique of providing high precision positional and Doppler measurements of planetary spacecraft using the Mars Express spacecraft. The technique will be used in the framework of Planetary Radio Interferometry and Doppler Experiments in various planetary missions, in particular in fly-by mode. Methods. We advanced a novel approach to spacecraft data processing using the techniques of Doppler and phase-referenced very long baseline interferometry spacecraft tracking. Results. We achieved, on average, mHz precision (30 μm/s at a 10 s integration time) for radial three-way Doppler estimates and sub-nanoradian precision for lateral position measurements, which in a linear measure (at a distance of 1.4 AU) corresponds to ∼50 m.