Browsing by Author "Wang, Jinfen"

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  • Flexible Micropillar Electrode Arrays for In Vivo Neural Activity Recordings
    (2019-05-17) Du, Mingde; Guan, Shouliang; Gao, Lei; Lv, Suye; Yang, Siting; Shi, Jidong; Wang, Jinfen; Li, Hongbian; Fang, Ying
     A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
    Flexible electronics that can form tight interfaces with neural tissues hold great promise for improving the diagnosis and treatment of neurological disorders and advancing brain/machine interfaces. Here, the facile fabrication of a novel flexible micropillar electrode array (µPEA) is described based on a biotemplate method. The flexible and compliant µPEA can readily integrate with the soft surface of a rat cerebral cortex. Moreover, the recording sites of the µPEA consist of protruding micropillars with nanoscale surface roughness that ensure tight interfacing and efficient electrical coupling with the nervous system. As a result, the flexible µPEA allows for in vivo multichannel recordings of epileptiform activity with a high signal-to-noise ratio of 252 ± 35. The ease of preparation, high flexibility, and biocompatibility make the µPEA an attractive tool for in vivo spatiotemporal mapping of neural activity.
  • Magnetic actuation of flexible microelectrode arrays for neural activity recordings
    (2019-10-03) Gao, Lei; Wang, Jinfen; Guan, Shouliang; Du, Mingde; Wu, Kun; Xu, Ke; Zou, Liang; Tian, Huihui; Fang, Ying
     A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
    Implantable microelectrodes that can be remotely actuated via external fields are promising tools to interface with biological systems at a high degree of precision. Here, we report the development of flexible magnetic microelectrodes (FMμEs) that can be remotely actuated by magnetic fields. The FMμEs consist of flexible microelectrodes integrated with dielectrically encapsulated FeNi (iron-nickel) alloy microactuators. Both magnetic torque- and force-driven actuation of the FMμEs have been demonstrated. Nano-platinum coated FMµEs have been applied for in vivo recordings of neural activities from peripheral nerves and cerebral cortex of mice. Moreover, owing to their ultra-small sizes and mechanical compliance with neural tissues, chronically implanted FMµEs elicited greatly reduced neuronal cell loss in mouse brain compared to conventional stiff probes. The FMµEs open up a variety of new opportunities for electrically interfacing with biological systems in a controlled and minimally-invasive manner.