Browsing by Author "Halkola, Tuomas"
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Elektroniikan, tietoliikenteen ja automaation tiedekunta | Bachelor's thesis(2009) Halkola, Tuomas - Nanos-in-Micros: Combining Drug Nanoparticles within Microparticles for Inhalation Therapy
Sähkötekniikan korkeakoulu | Master's thesis(2016-04-04) Halkola, TuomasModern drug development is often hindered by low solubility of new drug particles and the need for multiple drug molecules. A way to counteract the low solubility is to create nanoparticles of the drug. This, however, leads to issues in administration of the drug such as the need for a carrier powder in inhalation therapy. This work introduces a synthesis method of a drug particle that has multiple nanosized drugs encased within a micron-sized carrier particle. A nanosuspension of water and naproxen – a poorly soluble drug – is created using a ball mill. The resulting nanosuspension is mixed with cimetidine – a drug often administered with naproxen. Mannitol and leucine are added to form the matrix and the coating layer of the synthesized particle. The resulting solution is then run through an aerosol flow reactor. The “Nanos-in-Micros” particles and the powder made thereof are studied with multiple different methods. The particles assembled were found to exhibit most of the expected properties. As such, the “Nanos-in-Micros” concept is deemed a promising tool for pharmaceutical nanoparticle processing and further research is suggested.