Browsing by Author "Costa, M. M."

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45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response
(2018-12-15) Melo-Fonseca, F.; Lima, R.; Costa, M. M.; Bartolomeu, F.; Alves, N.; Miranda, A.; Gasik, M.; Silva, F. S.; Silva, N. A.; Miranda, G.
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Multi-material Ti6Al4V cellular structures impregnated with 45S5 bioactive glass were designed and produced using Selective Laser Melting (SLM), an additive manufacturing technique, combined with Press and Sintering focusing on load bearing components like hip implants. These structures were designed to combine Ti6Al4V mechanical properties and promote bone ingrowth into the structure as the bioactive material (45S5) is being absorbed and replaced by newly formed bone. The influence of these structures design on some of the physical and chemical aspects that drive cellular response was assessed. Roughness, wettability, bioactive glass quantity and quality on the structures after processing and the pH measured during cell culture (as a consequence of bioactive glass dissolution) were evaluated and correlated with cellular viability, cellular distribution, morphology and proliferation on the surface and inside the structures.
Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance
(2022-07) Costa, M. M.; Lima, R.; Alves, N.; Silva, N. A.; Gasik, M.; Silva, F. S.; Bartolomeu, F.; Miranda, G.
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance.