Browsing by Author "Agarwal, Ashok"

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Comprehensive Analysis of Global Research on Human Varicocele: A Scientometric Approach
(2022-10) Agarwal, Ashok; Finelli, Renata; Durairajanayagam, Damayanthi; Leisegang, Kristian; Henkel, Ralf; Salvio, Gianmaria; Aghamajidi, Azin; Sengupta, Pallav; Crisostomo, Luis; Tsioulou, Petroula A.; Roychoudhury, Shubhadeep; Finocchi, Federica; Darbandi, Mahsa; Mottola, Filomena; Darbandi, Sara; Iovine, Concetta; Santonastaso, Marianna; Zaker, Himasadat; Kesari, Kavindra Kumar; Nomanzadeh, Amir; Gugnani, Nivita; Rambhatla, Amarnath; Duran, Mesut Berkan; Ceyhan, Erman; Kandil, Hussein; Arafa, Mohamed; Saleh, Ramadan; Shah, Rupin; Boitrelle, Florence
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Purpose: This study provides a comprehensive analysis of research trends on the etiology, mechanisms, potential risk factors, diagnosis, prognosis, surgical and non-surgical treatment of varicocele, and clinical outcomes before and after varicocele repair. Materials and Methods: Varicocele studies published between 1988 and 2020 were retrieved from the Scopus database on April 5, 2021. Original studies on human varicocele were included, irrespective of language. Retrieved articles were manually screened for inclusion in various sub-categories. Bibliometric data was subjected to scientometric analysis using descriptive statistics. Network, heat and geographic mapping were generated using relevant software. Results: In total, 1,943 original human studies on varicocele were published. These were predominantly from the northern hemisphere and developed countries, and published in journals from the United States and Germany. Network map analysis for countries showed several interconnected nodal points, with the USA being the largest, and Agarwal A. from Cleveland Clinic, USA, being a center point of worldwide varicocele research collaborations. Studies of adolescents were underrepresented compared with studies of adults. Studies on diagnostic and prognostic aspects of varicocele were more numerous than studies on varicocele prevalence, mechanistic studies and studies focusing on etiological and risk factors. Varicocele surgery was more investigated than non-surgical approaches. To evaluate the impact of varicocele and its treatment, researchers mainly analyzed basic semen parameters, although markers of seminal oxidative stress are being increasingly investigated in the last decade, while reproductive outcomes such as live birth rate were under-reported in the literature. Conclusions: This study analyzes the publication trends in original research on human varicocele spanning over the last three decades. Our analysis emphasizes areas for further exploration to better understand varicocele's impact on men's health and male fertility.
Radiations and male fertility
(2018-12-09) Kesari, Kavindra Kumar; Agarwal, Ashok; Henkel, Ralf
A2 Katsausartikkeli tieteellisessä aikakauslehdessä
During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense exposure to heat and extreme exposure to pesticides, radiations, radioactivity and other hazardous substances. We are surrounded by several types of ionizing and non-ionizing radiations and both have recognized causative effects on spermatogenesis. Since it is impossible to cover all types of radiation sources and their biological effects under a single title, this review is focusing on radiation deriving from cell phones, laptops, Wi-Fi and microwave ovens, as these are the most common sources of non-ionizing radiations, which may contribute to the cause of infertility by exploring the effect of exposure to radiofrequency radiations on the male fertility pattern. From currently available studies it is clear that radiofrequency electromagnetic fields (RF-EMF) have deleterious effects on sperm parameters (like sperm count, morphology, motility), affects the role of kinases in cellular metabolism and the endocrine system, and produces genotoxicity, genomic instability and oxidative stress. This is followed with protective measures for these radiations and future recommendations. The study concludes that the RF-EMF may induce oxidative stress with an increased level of reactive oxygen species, which may lead to infertility. This has been concluded based on available evidences from in vitro and in vivo studies suggesting that RF-EMF exposure negatively affects sperm quality.